FKBP2 and C1QC

Data Source:
HPRD (in vitro, two hybrid)

		FKBP2	C1QC
Description		FKBP prolyl isomerase 2	complement C1q C chain
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane	Extracellular Region Collagen Trimer Extracellular Space Synapse Collagen-containing Extracellular Matrix Blood Microparticle Postsynapse
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding	Protein Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization	Immune Response Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Negative Regulation Of Granulocyte Differentiation Innate Immune Response Negative Regulation Of Macrophage Differentiation Synapse Pruning
Pathways			Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs			Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Crohn's disease ( 28067908) Fruit consumption ( 32066663)	Blood protein levels ( 30072576 29875488)
Interacting Genes		14 interacting genes: ARFGEF1 BAG6 BARD1 C1QC EPB41 EPB41L2 MAPK3 RAB3C RAB6A RAP2A UBQLN1 UBQLN2 UBQLN4 VAMP2	6 interacting genes: C1QA C1QB FKBP2 PTX3 UBQLN2 ZNF534
Entrez ID		2286	714
HPRD ID		01742	00395
Ensembl ID		ENSG00000173486	ENSG00000159189
Uniprot IDs		P26885 Q53XJ5	A0A024RAA7 P02747
PDB IDs		2PBC 4NNR	1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V
Enriched GO Terms of Interacting Partners?
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