FGFR2 and PPM1A

Data Source:
BioGRID (two hybrid)

		FGFR2	PPM1A
Description		fibroblast growth factor receptor 2	protein phosphatase, Mg2+/Mn2+ dependent 1A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Integral Component Of Membrane Cytoplasmic Vesicle Receptor Complex Excitatory Synapse Collagen-containing Extracellular Matrix	Nucleus Nucleoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Protein Binding Manganese Ion Binding Calmodulin-dependent Protein Phosphatase Activity R-SMAD Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Angiogenesis Ureteric Bud Development In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Mesenchymal Cell Proliferation Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Endochondral Bone Growth Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Multicellular Organism Development Axonogenesis Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Smoothened Signaling Pathway Post-embryonic Development Embryonic Pattern Specification Animal Organ Morphogenesis Positive Regulation Of Phospholipase Activity Negative Regulation Of Keratinocyte Proliferation Morphogenesis Of Embryonic Epithelium Peptidyl-tyrosine Phosphorylation Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Pyramidal Neuron Development Gland Morphogenesis Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Lung Development Epithelial Cell Differentiation Midbrain Development Otic Vesicle Formation Hair Follicle Morphogenesis Response To Lipopolysaccharide Lacrimal Gland Development Positive Regulation Of Kinase Activity Regulation Of Osteoblast Proliferation Organ Growth Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Wound Healing Inner Ear Morphogenesis Odontogenesis Positive Regulation Of MAPK Cascade Cell Fate Commitment Response To Ethanol Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Lung Alveolus Development Mesodermal Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Digestive Tract Development Embryonic Organ Development Reproductive Structure Development Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Epidermis Morphogenesis Branching Morphogenesis Of A Nerve Mesenchymal Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Ventricular Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Limb Bud Formation Bone Development Bone Morphogenesis Branching Involved In Prostate Gland Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Elongation Involved In Lung Branching Lung Lobe Morphogenesis Lung-associated Mesenchyme Development Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Prostate Gland Morphogenesis Prostate Epithelial Cord Elongation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Lateral Sprouting From An Epithelium Mammary Gland Bud Formation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Branch Elongation Involved In Salivary Gland Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Mesenchymal Cell Differentiation Involved In Lung Development Mesenchymal Cell Proliferation Involved In Lung Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation N-terminal Protein Myristoylation Cell Cycle Arrest Negative Regulation Of SMAD Protein Complex Assembly Dephosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Peptidyl-threonine Dephosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Export From Nucleus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		Signaling by FGFR2 amplification mutants Activated point mutants of FGFR2 Signaling by FGFR2 in disease Signaling by FGFR2 IIIa TM Signaling by FGFR2 fusions	Downregulation of SMAD2/3:SMAD4 transcriptional activity Energy dependent regulation of mTOR by LKB1-AMPK
Drugs		Palifermin Thalidomide Heparin Sucrosofate 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine Regorafenib Ponatinib Lenvatinib Nintedanib Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Fostamatinib Erdafitinib Pemigatinib Selpercatinib Pralsetinib
Diseases		Gastric cancer Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Adiponectin levels ( 24105470) Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Body mass index ( 28892062) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 21263130 20872241 24143190 23354978 29059683 17529967 23535729 17529973 22951594 31757997 20453838 25956309 19330030) Breast cancer (early onset) ( 24493630) Breast cancer (estrogen-receptor positive) ( 28864454) Breast cancer (progesterone-receptor positive) ( 28864454) Breast cancer in BRCA2 mutation carriers ( 23544012 21060860) Cancer (pleiotropy) ( 27197191) Childhood ear infection ( 27182965) Core binding factor acute myeloid leukemia ( 27903959) Coronary artery disease ( 32469254) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estrogen receptor status in breast cancer ( 27764800) Estrogen receptor status in HER2 negative breast cancer ( 27764800) High density lipoprotein cholesterol levels ( 29403010) Magnesium levels ( 26685716) PR interval ( 32439900) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 30410027 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Serum prostate-specific antigen levels ( 21160077) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647 30718926) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Allergic rhinitis ( 22036096) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hair color ( 29662168) Hip circumference adjusted for BMI ( 25673412) Menarche (age at onset) ( 27182965) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		46 interacting genes: ANOS1 APP BEX1 BEX2 CACNA1D CTDSP1 CTDSPL DUSP14 EPHA4 ERBB2 ERRFI1 FBXO7 FGF1 FGF10 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GLCE HOXC6 ITGA5 LRRK1 MTA3 MTMR3 NECTIN1 NEDD4 PAK4 PDLIM2 PLCG1 PPM1A PTK2B PTPN11 PTPN12 PTPRR RASL10B RHOBTB2 S100A14 SHC1 TFF1	37 interacting genes: AATK AKT1 ALK CACNA1A CACNA1B CACNA1C CDC42BPA CDC42BPB CTNNB1 DVL1 DVL2 DVL3 EEF2 EGFR ERBB2 ERBB3 ERBB4 FGFR2 GRM3 HSPB1 IGF1R KDR LMTK2 MSN NR4A1 PAK1 PAK2 PIK3R1 PLK3 PRKAA1 PRKCA PRKCD PTK7 ROR2 RPLP0 SMAD2 SMAD3
Entrez ID		2263	5494
HPRD ID		01492	16199
Ensembl ID		ENSG00000066468	ENSG00000100614
Uniprot IDs		A0A141AXF1 D2CGD1 P21802 S4R381	A0A024R6A5 B2R8E4 P35813
PDB IDs		1DJS 1E0O 1EV2 1GJO 1II4 1IIL 1NUN 1OEC 1WVZ 2FDB 2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B 3B2T 3CAF 3CLY 3CU1 3DAR 3EUU 3OJ2 3OJM 3RI1 4J23 4J95 4J96 4J97 4J98 4J99 4WV1 5EG3 5UGL 5UGX 5UHN 5UI0 6AGX 6LVK 6LVL	1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO 4RA2 4RAF 4RAG 6B67
Enriched GO Terms of Interacting Partners?
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