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FGFR2 and FGF17
Data Source:
BioGRID
(unspecified method)
HPRD
(in vitro)
FGFR2
FGF17
Description
fibroblast growth factor receptor 2
fibroblast growth factor 17
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Cortex
Cell Surface
Membrane
Integral Component Of Membrane
Cytoplasmic Vesicle
Receptor Complex
Excitatory Synapse
Collagen-containing Extracellular Matrix
Extracellular Region
Extracellular Space
Cytoplasm
Molecular Function
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Fibroblast Growth Factor-activated Receptor Activity
Protein Binding
ATP Binding
Heparin Binding
Fibroblast Growth Factor Binding
Protein Homodimerization Activity
Fibroblast Growth Factor Receptor Binding
Type 1 Fibroblast Growth Factor Receptor Binding
Type 2 Fibroblast Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Angiogenesis
Ureteric Bud Development
In Utero Embryonic Development
Epithelial To Mesenchymal Transition
Positive Regulation Of Mesenchymal Cell Proliferation
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Endochondral Bone Growth
Apoptotic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Signaling
Multicellular Organism Development
Axonogenesis
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Smoothened Signaling Pathway
Post-embryonic Development
Embryonic Pattern Specification
Animal Organ Morphogenesis
Positive Regulation Of Phospholipase Activity
Negative Regulation Of Keratinocyte Proliferation
Morphogenesis Of Embryonic Epithelium
Peptidyl-tyrosine Phosphorylation
Orbitofrontal Cortex Development
Ventricular Zone Neuroblast Division
Pyramidal Neuron Development
Gland Morphogenesis
Positive Regulation Of Wnt Signaling Pathway
Bone Mineralization
Lung Development
Epithelial Cell Differentiation
Midbrain Development
Otic Vesicle Formation
Hair Follicle Morphogenesis
Response To Lipopolysaccharide
Lacrimal Gland Development
Positive Regulation Of Kinase Activity
Regulation Of Osteoblast Proliferation
Organ Growth
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development
Wound Healing
Inner Ear Morphogenesis
Odontogenesis
Positive Regulation Of MAPK Cascade
Cell Fate Commitment
Response To Ethanol
Regulation Of Osteoblast Differentiation
Positive Regulation Of Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
Lung Alveolus Development
Mesodermal Cell Differentiation
Embryonic Digestive Tract Morphogenesis
Embryonic Organ Morphogenesis
Digestive Tract Development
Embryonic Organ Development
Reproductive Structure Development
Positive Regulation Of Smooth Muscle Cell Proliferation
Embryonic Cranial Skeleton Morphogenesis
Skeletal System Morphogenesis
Epidermis Morphogenesis
Branching Morphogenesis Of A Nerve
Mesenchymal Cell Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Ventricular Cardiac Muscle Tissue Morphogenesis
Positive Regulation Of Cardiac Muscle Cell Proliferation
Limb Bud Formation
Bone Development
Bone Morphogenesis
Branching Involved In Prostate Gland Morphogenesis
Branching Involved In Salivary Gland Morphogenesis
Bud Elongation Involved In Lung Branching
Lung Lobe Morphogenesis
Lung-associated Mesenchyme Development
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Prostate Gland Morphogenesis
Prostate Epithelial Cord Elongation
Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis
Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification
Lateral Sprouting From An Epithelium
Mammary Gland Bud Formation
Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis
Branch Elongation Involved In Salivary Gland Morphogenesis
Branching Involved In Labyrinthine Layer Morphogenesis
Regulation Of Morphogenesis Of A Branching Structure
Mesenchymal Cell Differentiation Involved In Lung Development
Mesenchymal Cell Proliferation Involved In Lung Development
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Retinoic Acid
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
MAPK Cascade
Positive Regulation Of Protein Phosphorylation
Signal Transduction
Cell-cell Signaling
Nervous System Development
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Animal Organ Morphogenesis
Positive Regulation Of Gene Expression
Cell Differentiation
Regulation Of Cell Migration
Positive Regulation Of Protein Kinase B Signaling
Pathways
Signaling by FGFR2 amplification mutants
Activated point mutants of FGFR2
Signaling by FGFR2 in disease
Signaling by FGFR2 IIIa TM
Signaling by FGFR2 fusions
Drugs
Palifermin
Thalidomide
Heparin
Sucrosofate
3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone
4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Fostamatinib
Erdafitinib
Pemigatinib
Selpercatinib
Pralsetinib
Diseases
Gastric cancer
Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome
Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS
Adiponectin levels (
24105470
)
Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) (
32595297
)
Benign prostatic hyperplasia and lower urinary tract symptoms (
30410027
)
Body mass index (
28892062
)
BRCA1/2-negative high-risk breast cancer (
30323354
)
Breast cancer (
21263130
20872241
24143190
23354978
29059683
17529967
23535729
17529973
22951594
31757997
20453838
25956309
19330030
)
Breast cancer (early onset) (
24493630
)
Breast cancer (estrogen-receptor positive) (
28864454
)
Breast cancer (progesterone-receptor positive) (
28864454
)
Breast cancer in BRCA2 mutation carriers (
23544012
21060860
)
Cancer (pleiotropy) (
27197191
)
Childhood ear infection (
27182965
)
Core binding factor acute myeloid leukemia (
27903959
)
Coronary artery disease (
32469254
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Estrogen receptor status in breast cancer (
27764800
)
Estrogen receptor status in HER2 negative breast cancer (
27764800
)
High density lipoprotein cholesterol levels (
29403010
)
Magnesium levels (
26685716
)
PR interval (
32439900
)
Prostate cancer (
31562322
)
Prostate-specific antigen levels (
30410027
28139693
)
Prostate-specific antigen levels (conditioned on lead SNPs) (
28139693
)
Serum prostate-specific antigen levels (
21160077
)
Systolic blood pressure (
30224653
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
32499647
30718926
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Interacting Genes
46 interacting genes:
ANOS1
APP
BEX1
BEX2
CACNA1D
CTDSP1
CTDSPL
DUSP14
EPHA4
ERBB2
ERRFI1
FBXO7
FGF1
FGF10
FGF17
FGF18
FGF2
FGF23
FGF3
FGF4
FGF5
FGF6
FGF7
FGF8
FGF9
GLCE
HOXC6
ITGA5
LRRK1
MTA3
MTMR3
NECTIN1
NEDD4
PAK4
PDLIM2
PLCG1
PPM1A
PTK2B
PTPN11
PTPN12
PTPRR
RASL10B
RHOBTB2
S100A14
SHC1
TFF1
6 interacting genes:
FGFR1
FGFR2
FGFR3
FGFR4
PTX3
UBQLN2
Entrez ID
2263
8822
HPRD ID
01492
04765
Ensembl ID
ENSG00000066468
ENSG00000158815
Uniprot IDs
A0A141AXF1
D2CGD1
P21802
S4R381
O60258
PDB IDs
1DJS
1E0O
1EV2
1GJO
1II4
1IIL
1NUN
1OEC
1WVZ
2FDB
2PSQ
2PVF
2PVY
2PWL
2PY3
2PZ5
2PZP
2PZR
2Q0B
3B2T
3CAF
3CLY
3CU1
3DAR
3EUU
3OJ2
3OJM
3RI1
4J23
4J95
4J96
4J97
4J98
4J99
4WV1
5EG3
5UGL
5UGX
5UHN
5UI0
6AGX
6LVK
6LVL
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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