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LNX2 and PSMD5
Data Source:
BioGRID
(two hybrid)
LNX2
PSMD5
Description
ligand of numb-protein X 2
proteasome 26S subunit, non-ATPase 5
Image
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Proteasome Accessory Complex
Molecular Function
Protein Binding
PDZ Domain Binding
Identical Protein Binding
Metal Ion Binding
Protein Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Proteasome Regulatory Particle Assembly
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Body mass index (
26426971
28892062
)
Large B-cell lymphoma (
21471979
)
Mean platelet volume (
32888494
27863252
)
Night sleep phenotypes (
27126917
)
Platelet distribution width (
32888494
27863252
)
Response to cytadine analogues (cytosine arabinoside) (
24483146
)
Systolic blood pressure (
27618452
)
Interacting Genes
89 interacting genes:
ATP5F1B
C10orf88
CABP4
CBX4
CCT3
CDK2
CDK4
CDKN2C
CRK
CXADR
DDA1
DRAP1
EAF2
FANCG
FHL3
GADD45A
GJD2
GLRX3
GRAP2
GRB2
IGSF5
IL16
INMT
IP6K2
L3MBTL2
LGALS14
LNX1
LRRC8E
MAP2K5
MAPK9
MCM7
MDGA1
MLX
MRFAP1L1
MSRB3
MYLIP
NAGK
NMD3
NOTCH1
NTAQ1
NUDT14
NUMB
OPTN
PARVG
PDZRN3
PDZRN4
PEG10
PHYKPL
PIK3R1
PIK3R3
PKDREJ
POLR1C
PPIH
PPIL1
PSMD5
PSMF1
PTCD3
RAB6B
RBM17
RLIM
RNF138
ROPN1
RPA2
SCLY
SCNM1
SFN
SH3GLB2
SHISA2
SHTN1
SMARCB1
SRSF11
TAB1
TBC1D7
TCL1A
TIFA
TRAF1
TRAF2
TUBB
UBE2D2
UBE2H
UBE2I
UBE2T
UBE2Z
USP2
VTN
YJU2
ZNF148
ZNF410
ZNF581
10 interacting genes:
APP
BTBD1
BTBD2
CASTOR1
LNX2
PSMC1
PSMC2
PSMD2
TFCP2
UBC
Entrez ID
222484
5711
HPRD ID
10042
05121
Ensembl ID
ENSG00000139517
ENSG00000095261
Uniprot IDs
Q8N448
Q16401
PDB IDs
2VWR
5DIN
5E11
5E1Y
5E21
5E22
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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