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LNX2 and RPA2
Data Source:
BioGRID
(two hybrid)
LNX2
RPA2
Description
ligand of numb-protein X 2
replication protein A2
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Nuclear Body
PML Body
Site Of Double-strand Break
Molecular Function
Protein Binding
PDZ Domain Binding
Identical Protein Binding
Metal Ion Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Protein N-terminus Binding
G-rich Strand Telomeric DNA Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Regulation Of Double-strand Break Repair Via Homologous Recombination
Translesion Synthesis
Mitotic G1 DNA Damage Checkpoint
Telomere Maintenance Via Semi-conservative Replication
Nucleotide-excision Repair, DNA Incision
Protein Localization To Chromosome
Interstrand Cross-link Repair
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Error-free Translesion Synthesis
Regulation Of Cellular Response To Heat
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of DNA Damage Checkpoint
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
Drugs
Diseases
GWAS
Body mass index (
26426971
28892062
)
Large B-cell lymphoma (
21471979
)
Mean platelet volume (
32888494
27863252
)
Night sleep phenotypes (
27126917
)
Platelet distribution width (
32888494
27863252
)
Response to cytadine analogues (cytosine arabinoside) (
24483146
)
HDL cholesterol levels (
32203549
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
89 interacting genes:
ATP5F1B
C10orf88
CABP4
CBX4
CCT3
CDK2
CDK4
CDKN2C
CRK
CXADR
DDA1
DRAP1
EAF2
FANCG
FHL3
GADD45A
GJD2
GLRX3
GRAP2
GRB2
IGSF5
IL16
INMT
IP6K2
L3MBTL2
LGALS14
LNX1
LRRC8E
MAP2K5
MAPK9
MCM7
MDGA1
MLX
MRFAP1L1
MSRB3
MYLIP
NAGK
NMD3
NOTCH1
NTAQ1
NUDT14
NUMB
OPTN
PARVG
PDZRN3
PDZRN4
PEG10
PHYKPL
PIK3R1
PIK3R3
PKDREJ
POLR1C
PPIH
PPIL1
PSMD5
PSMF1
PTCD3
RAB6B
RBM17
RLIM
RNF138
ROPN1
RPA2
SCLY
SCNM1
SFN
SH3GLB2
SHISA2
SHTN1
SMARCB1
SRSF11
TAB1
TBC1D7
TCL1A
TIFA
TRAF1
TRAF2
TUBB
UBE2D2
UBE2H
UBE2I
UBE2T
UBE2Z
USP2
VTN
YJU2
ZNF148
ZNF410
ZNF581
63 interacting genes:
ACP5
AKAP9
APP
ATM
CALCOCO2
CASK
CCNC
CCNO
CDC5L
CDK1
CEP126
CFB
COPS6
CRMP1
DMRTB1
EEF1A1
EIF4G2
ERCC1
ERCC4
GAPDH
GOLM1
HERPUD1
HNRNPUL1
HUS1
LNX2
LRIF1
MARK2
MCM2
MCM5
MED1
MED31
MEN1
NDEL1
ORC1
ORC2
ORC4
ORC5
PCM1
PPP4C
PRC1
PRKCI
PRKDC
RAD1
RAD51
RAD52
RAD9A
RBM14
RBM48
RPA1
RPA3
RPLP1
SDF4
SERTAD3
SLC17A9
STAT3
TLE1
TUBB2A
UNC119
UNG
UTP14A
XPA
YWHAE
ZBTB14
Entrez ID
222484
6118
HPRD ID
10042
01566
Ensembl ID
ENSG00000139517
ENSG00000117748
Uniprot IDs
Q8N448
B4DUL2
P15927
PDB IDs
2VWR
5DIN
5E11
5E1Y
5E21
5E22
1DPU
1L1O
1QUQ
1Z1D
2PI2
2PQA
2Z6K
3KDF
4MQV
4OU0
Enriched GO Terms of Interacting Partners
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