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LNX2 and UBE2D2
Data Source:
BioGRID
(pull down)
LNX2
UBE2D2
Description
ligand of numb-protein X 2
ubiquitin conjugating enzyme E2 D2
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytosol
Protein-containing Complex
Extracellular Exosome
Molecular Function
Protein Binding
PDZ Domain Binding
Identical Protein Binding
Metal Ion Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Protein Polyubiquitination
MyD88-independent Toll-like Receptor Signaling Pathway
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Protein Targeting To Peroxisome
Protein Ubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
(R,R)-2,3-Butanediol
Diseases
GWAS
Body mass index (
26426971
28892062
)
Large B-cell lymphoma (
21471979
)
Mean platelet volume (
32888494
27863252
)
Night sleep phenotypes (
27126917
)
Platelet distribution width (
32888494
27863252
)
Response to cytadine analogues (cytosine arabinoside) (
24483146
)
Alzheimer's disease (late onset) (
30820047
)
Body mass index (
26426971
)
Immune reponse to smallpox (secreted IFN-alpha) (
22610502
)
Leukocyte telomere length (
32109421
)
Interacting Genes
89 interacting genes:
ATP5F1B
C10orf88
CABP4
CBX4
CCT3
CDK2
CDK4
CDKN2C
CRK
CXADR
DDA1
DRAP1
EAF2
FANCG
FHL3
GADD45A
GJD2
GLRX3
GRAP2
GRB2
IGSF5
IL16
INMT
IP6K2
L3MBTL2
LGALS14
LNX1
LRRC8E
MAP2K5
MAPK9
MCM7
MDGA1
MLX
MRFAP1L1
MSRB3
MYLIP
NAGK
NMD3
NOTCH1
NTAQ1
NUDT14
NUMB
OPTN
PARVG
PDZRN3
PDZRN4
PEG10
PHYKPL
PIK3R1
PIK3R3
PKDREJ
POLR1C
PPIH
PPIL1
PSMD5
PSMF1
PTCD3
RAB6B
RBM17
RLIM
RNF138
ROPN1
RPA2
SCLY
SCNM1
SFN
SH3GLB2
SHISA2
SHTN1
SMARCB1
SRSF11
TAB1
TBC1D7
TCL1A
TIFA
TRAF1
TRAF2
TUBB
UBE2D2
UBE2H
UBE2I
UBE2T
UBE2Z
USP2
VTN
YJU2
ZNF148
ZNF410
ZNF581
252 interacting genes:
AMFR
ANAPC11
ANAPC2
AREL1
ARIH2
ARRDC3
BARD1
BFAR
BIRC2
BIRC3
BIRC7
BIRC8
BMI1
BRAP
BRCA1
BTRC
CADPS2
CBL
CBLB
CBLC
CCNB1
CDKN1B
CHFR
CNOT4
COP1
CUEDC1
CUL3
CYLD
DCAF1
DDX58
DLST
DTX1
DTX2
DTX3
DTX3L
DZIP3
EPS15
F12
FBXL17
FBXL3
FBXO2
FBXO4
FBXO7
FBXW2
FOXO1
G0S2
H3C1
H4C1
HACE1
HECTD1
HECTD3
HECTD4
HECW1
HECW2
HERC1
HERC2
HERC4
HERC5
HUWE1
ILF3
ITCH
KAT2B
KCMF1
LNX1
LNX2
LRSAM1
LTN1
MAEA
MAP3K1
MAPT
MARCHF3
MARCHF5
MARCHF6
MARCHF7
MDM2
MDM4
MEX3A
MEX3C
MGRN1
MIB1
MIB2
MID1
MID2
MKRN3
MUL1
MYCBP2
MYLIP
NAT10
NBR1
NEDD4
NEDD4L
NFKBIA
NPR1
NSMCE1
OTUB1
PDZRN3
PELI1
PER2
PHF7
PHRF1
PJA1
PJA2
POLL
POLM
PRKN
QSOX1
RAD18
RAF1
RAG1
RBCK1
RBX1
RC3H1
RC3H2
RCHY1
RELA
RFFL
RFWD3
RING1
RLIM
RMND5A
RMND5B
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF123
RNF125
RNF126
RNF13
RNF130
RNF135
RNF138
RNF14
RNF146
RNF150
RNF151
RNF166
RNF167
RNF168
RNF170
RNF181
RNF185
RNF186
RNF19A
RNF19B
RNF2
RNF20
RNF213
RNF216
RNF220
RNF224
RNF25
RNF26
RNF31
RNF34
RNF38
RNF4
RNF40
RNF43
RNF5
RNF7
RNF8
RSPRY1
RTF2
SIAH1
SIAH2
SMURF1
SMURF2
SNCA
SOCS6
SPOP
SQSTM1
STAM2
STK11
STUB1
SYVN1
TOPORS
TRAF2
TRAF6
TRAF7
TRAIP
TRIM10
TRIM13
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM33
TRIM35
TRIM36
TRIM37
TRIM38
TRIM39
TRIM41
TRIM43
TRIM45
TRIM46
TRIM47
TRIM5
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TRIM65
TRIM7
TRIM8
TRIP12
TTC3
UBA1
UBA3
UBA5
UBA6
UBASH3B
UBB
UBC
UBD
UBE3A
UBE3C
UBE4A
UBE4B
UBOX5
UBR1
UBR2
UBR3
UBR4
UBR5
UBTD1
UFM1
UHRF2
UVSSA
VHL
VPS11
VPS18
WRN
WSB1
WWP1
WWP2
XIAP
ZNRF1
ZNRF2
ZNRF4
Entrez ID
222484
7322
HPRD ID
10042
04268
Ensembl ID
ENSG00000139517
ENSG00000131508
Uniprot IDs
Q8N448
P62837
PDB IDs
2VWR
5DIN
5E11
5E1Y
5E21
5E22
1UR6
1W4U
2CLW
2ESK
2ESO
2ESP
2ESQ
3A33
3JVZ
3JW0
3L1Y
3TGD
3ZNI
4A49
4A4B
4A4C
4AUQ
4DDG
4DDI
4LDT
4V3K
4V3L
4WZ3
5D0K
5D0M
5D1K
5D1L
5D1M
5EDV
5MNJ
5ULF
5ULH
5ULK
5VZW
5ZBU
6HPR
6SQO
6SQR
6SQS
6TTU
6W7Z
6W9D
Enriched GO Terms of Interacting Partners
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