BEND7 and SMARCA2

Data Source:
BioGRID (two hybrid, two hybrid)

		BEND7	SMARCA2
Description		BEN domain containing 7	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Exosome	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex
	Molecular Function	Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Histone Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spermatid Development Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways			RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Diastolic blood pressure ( 30224653) Free thyroxine concentration ( 30367059) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) PR interval ( 32439900) Skin pigmentation ( 28300201) Smoking status (ever vs never smokers) ( 30643258) White blood cell count ( 32888494)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma (childhood onset) ( 27611488) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Brain morphology (MOSTest) ( 32665545) Lead levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Monobrow ( 27182965) Neuritic plaque ( 31497858) Nose size ( 27182965) Parkinson's disease ( 26227905) Superior frontal gyrus grey matter volume ( 25335168) Systolic blood pressure ( 26969751) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955)
Interacting Genes		73 interacting genes: ANP32B BANF2 BYSL C14orf119 CDC37 CDCA7L CEP44 CHD2 CIB3 CSNK2A1 DDX6 DVL2 DVL3 EAF1 EAF2 EIF1AD EMD FAM124A FAM133A GADD45G GEMIN2 GTPBP3 GYS1 HMBOX1 HSF2BP KANK2 L3MBTL2 LMO3 LNX1 LYAR MAGOHB MFAP1 MLX MORF4L1 MORF4L2 MYO15B NAP1L3 NEK6 NIF3L1 NKAPD1 NOL12 NUTF2 OSGIN1 PBLD PIM1 PLEKHF2 POLR3GL PPIG PPP1R37 PRMT3 PRPF40A PSMB1 PSMF1 RAB29 RBM10 RIPPLY1 RPL22 SCNM1 SDCBP SDCBP2 SMARCA2 SPANXN2 THAP1 TLK1 TNPO2 TRIM26 U2AF2 UBL5 USP20 VCX2 WHRN ZCCHC10 ZNF622	27 interacting genes: ACTL6A ACTL6B AR ARID1B BEND7 BRCA1 CEBPA ESR1 H3C1 HSPB1 KHDRBS1 MDM2 MDM4 MECP2 MYB MYC NR0B2 NR3C1 NR4A2 PHB PITX1 PRMT5 PRPF6 RAP1A SDCBP SIN3B SS18
Entrez ID		222389	6595
HPRD ID		12570	02483
Ensembl ID		ENSG00000165626	ENSG00000080503
Uniprot IDs		Q8N7W2	B1ALF6 B4DNT1 B4DSC8 F6T8Q0 F6VDE0 P51531 Q56A76 Q8N9Q1
PDB IDs			2DAT 4QY4 5DKC 5DKH 6EG2 6EG3 6HAX 6HAY 6HAZ
Enriched GO Terms of Interacting Partners?
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