FCN2 and MASP1

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		FCN2	MASP1
Description		ficolin 2	MBL associated serine protease 1
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Nucleoplasm Cytosol
	Molecular Function	Antigen Binding Signaling Receptor Binding Protein Binding Proteoglycan Binding Metal Ion Binding Calcium-dependent Protein Binding Carbohydrate Derivative Binding Mannan Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Complement Activation Opsonization Recognition Of Apoptotic Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Complement Activation, Lectin Pathway Proteolysis Receptor-mediated Endocytosis Complement Activation
Pathways		Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface	Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576) Impulsivity (attentional) ( 30718321) Type 2 diabetes ( 30130595)
Interacting Genes		2 interacting genes: MASP1 MASP2	16 interacting genes: C2 C3 FCN2 GADD45A GSK3B H2AX MAPK6 MAPK8IP2 MAPT MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1
Entrez ID		2220	5648
HPRD ID		03376	02749
Ensembl ID		ENSG00000160339	ENSG00000127241
Uniprot IDs		Q15485	F8W876 P48740
PDB IDs		2J0G 2J0H 2J0Y 2J1G 2J2P 2J3F 2J3G 2J3O 2J3U 2J61 4NYT 4R9J 4R9T	3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD
Enriched GO Terms of Interacting Partners?
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