FCN2 and MASP2

Data Source:
HPRD (in vitro)

		FCN2	MASP2
Description		ficolin 2	MBL associated serine protease 2
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Antigen Binding Signaling Receptor Binding Protein Binding Proteoglycan Binding Metal Ion Binding Calcium-dependent Protein Binding Carbohydrate Derivative Binding Mannan Binding	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Calcium-dependent Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Complement Activation Opsonization Recognition Of Apoptotic Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Complement Activation, Lectin Pathway Proteolysis Complement Activation Complement Activation, Classical Pathway
Pathways		Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface
Drugs			beta-Hydroxyasparagine
Diseases			Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency
GWAS		Blood protein levels ( 30072576 29875488)	Beard thickness ( 26926045) Body mass index ( 29273807) Eosinophil percentage of white cells ( 32888494) Male-pattern baldness ( 28196072)
Interacting Genes		2 interacting genes: MASP1 MASP2	4 interacting genes: C4A FCN2 MBL2 SERPING1
Entrez ID		2220	10747
HPRD ID		03376	05484
Ensembl ID		ENSG00000160339	ENSG00000009724
Uniprot IDs		Q15485	O00187
PDB IDs		2J0G 2J0H 2J0Y 2J1G 2J2P 2J3F 2J3G 2J3O 2J3U 2J61 4NYT 4R9J 4R9T	1Q3X 1SZB 1ZJK 3TVJ 4FXG 5JPM
Enriched GO Terms of Interacting Partners?
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