MASP2 and C4A

Data Source:
BioGRID (enzymatic study)

		MASP2	C4A
Description		MBL associated serine protease 2	complement C4A (Rodgers blood group)
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Axon Dendrite Neuronal Cell Body Synapse Extracellular Exosome Blood Microparticle
	Molecular Function	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Calcium-dependent Protein Binding	Complement Component C1q Complex Binding Endopeptidase Inhibitor Activity
	Biological Process	Complement Activation, Lectin Pathway Proteolysis Complement Activation Complement Activation, Classical Pathway	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways			Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade
Drugs		beta-Hydroxyasparagine	Human immunoglobulin G
Diseases		Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency Systemic lupus erythematosus
GWAS		Beard thickness ( 26926045) Body mass index ( 29273807) Eosinophil percentage of white cells ( 32888494) Male-pattern baldness ( 28196072)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Feeling worry ( 29500382) Inflammatory bowel disease ( 28067908) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908)
Interacting Genes		4 interacting genes: C4A FCN2 MBL2 SERPING1	7 interacting genes: APC APOA2 C3AR1 C5AR2 CR1 CST3 MASP2
Entrez ID		10747	720
HPRD ID		05484	00401
Ensembl ID		ENSG00000009724	ENSG00000244731
Uniprot IDs		O00187	P0C0L4
PDB IDs		1Q3X 1SZB 1ZJK 3TVJ 4FXG 5JPM	1HZF 4FXG 4FXK 4XAM 5JPM 5JPN 5JTW
Enriched GO Terms of Interacting Partners?
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