MASP2 and FCN2

Data Source:
HPRD (in vitro)

		MASP2	FCN2
Description		MBL associated serine protease 2	ficolin 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Extracellular Region Collagen Trimer Extracellular Space Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Calcium-dependent Protein Binding	Antigen Binding Signaling Receptor Binding Protein Binding Proteoglycan Binding Metal Ion Binding Calcium-dependent Protein Binding Carbohydrate Derivative Binding Mannan Binding
	Biological Process	Complement Activation, Lectin Pathway Proteolysis Complement Activation Complement Activation, Classical Pathway	Complement Activation, Lectin Pathway Complement Activation Opsonization Recognition Of Apoptotic Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways			Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface
Drugs		beta-Hydroxyasparagine
Diseases		Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency
GWAS		Beard thickness ( 26926045) Body mass index ( 29273807) Eosinophil percentage of white cells ( 32888494) Male-pattern baldness ( 28196072)	Blood protein levels ( 30072576 29875488)
Interacting Genes		4 interacting genes: C4A FCN2 MBL2 SERPING1	2 interacting genes: MASP1 MASP2
Entrez ID		10747	2220
HPRD ID		05484	03376
Ensembl ID		ENSG00000009724	ENSG00000160339
Uniprot IDs		O00187	Q15485
PDB IDs		1Q3X 1SZB 1ZJK 3TVJ 4FXG 5JPM	2J0G 2J0H 2J0Y 2J1G 2J2P 2J3F 2J3G 2J3O 2J3U 2J61 4NYT 4R9J 4R9T
Enriched GO Terms of Interacting Partners?
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