SKA3 and SPC24

Data Source:
BioGRID (two hybrid, two hybrid)

		SKA3	SPC24
Description		spindle and kinetochore associated complex subunit 3	SPC24 component of NDC80 kinetochore complex
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GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Outer Kinetochore Centrosome Cytosol Spindle Microtubule Mitotic Spindle	Condensed Chromosome Kinetochore Nucleoplasm Nucleolus Cytosol Ndc80 Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Regulation Of Microtubule Polymerization Or Depolymerization Cell Division	Cell Cycle Cell Division
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 33020668) Cortisol levels (saliva) ( 28843169) HDL cholesterol ( 23505323) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 30718733) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 31095298)
Interacting Genes		7 interacting genes: APP AURKB LRRK2 NOL4 SKA1 SPC24 ZDHHC17	8 interacting genes: APP PSEN2 SKA1 SKA2 SKA3 SPC25 SUOX WHRN
Entrez ID		221150	147841
HPRD ID		10706	15464
Ensembl ID		ENSG00000165480	ENSG00000161888
Uniprot IDs		Q8IX90	B4E086 Q8NBT2
PDB IDs		4AJ5	2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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