Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
CBY2 and TSC2
Data Source:
BioGRID
(two hybrid)
CBY2
TSC2
Description
chibby family member 2
TSC complex subunit 2
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cytoplasmic Vesicle
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Cytosol
Postsynaptic Density
Membrane
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
GTPase Activator Activity
Protein Binding
Phosphatase Binding
Small GTPase Binding
Protein Homodimerization Activity
Hsp90 Protein Binding
Biological Process
Neural Tube Closure
Negative Regulation Of Protein Kinase Activity
Protein Import Into Nucleus
Endocytosis
Heart Development
Protein Localization
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Vesicle-mediated Transport
Positive Regulation Of Macroautophagy
Regulation Of Endocytosis
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of TOR Signaling
Anoikis
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Chemotaxis
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Cell Cycle
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Mitophagy
Pathways
Macroautophagy
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
TBC/RABGAPs
Drugs
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Major depressive disorder (
29317602
)
Obesity-related traits (
23251661
)
White blood cell count (
32888494
)
Interacting Genes
119 interacting genes:
ACTN1
AIMP2
ARHGEF40
ARMC7
BEX3
C19orf44
C1orf109
CCDC146
CCDC185
CCDC187
CCDC198
CCDC57
CCHCR1
CCNG1
CDC23
CDC37
CDK18
CDK2
CEP44
CEP55
CEP57L1
CEP95
CHCHD3
CHIC2
CIBAR1
CKS1B
CNNM3
CYTH4
DGCR6
DTNB
DUSP14
DZIP1L
EFCAB3
EIF4E2
ELOA
ENKD1
FAM161A
FANCG
FARS2
FBXO17
FRS3
GADD45A
GADD45GIP1
GOLGA2
GOLGA6A
GOLGA6L2
GRAP2
HAUS1
HSF2BP
ING5
ISCU
KIAA0408
KIFC3
KLC3
LATS1
LENG1
LMO1
LMO2
LMO3
LNX1
MCRS1
MED28
METTL17
MLH1
MMAB
MOS
NDUFA5
NEK6
NINL
NME7
NTAQ1
OIP5
PID1
PIN1
PLEKHN1
POLR1C
PPFIA3
PPP1R13B
PPP1R18
PRPF18
PRPF31
RCOR3
RNF6
RPL9
RTP5
RUNX1T1
SCNM1
SDCBP
SH3RF2
SNAPC5
SSX3
SYCE1
SYT17
TCEA2
TCEANC
TCHP
TEX11
TRIM42
TRIML2
TSC2
TSGA10
TSGA10IP
TUBGCP4
TXK
TXLNA
TXLNB
USHBP1
ZC2HC1C
ZFYVE26
ZMAT2
ZNF250
ZNF417
ZNF564
ZNF572
ZNF581
ZNF655
ZNF688
ZNF764
ZNF785
44 interacting genes:
AKT1
AKT2
AKT3
CALM1
CBY2
CCND1
CDKN1B
ESR1
FBXL6
FBXW5
GRB2
GSK3B
LNX1
MAPK1
MAPK3
MAPKAPK2
MDFI
NEK1
PAM
PIN1
PLK2
PPP2CA
PRKAA1
PTK2
PTPN11
RAB5A
RABEP1
RHEB
RPS6KA1
SFN
SMAD2
SMAD3
SUPT6H
TK1
TRIM55
TRIM63
TSC1
UBE3A
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
220082
7249
HPRD ID
14856
01850
Ensembl ID
ENSG00000174015
ENSG00000103197
Uniprot IDs
A0A140VJV5
Q8NA61
B3KWH7
H3BMQ0
P49815
Q5HYF7
X5D7Q2
PDB IDs
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?