ALAS2 and RABGGTB

Data Source:
HPRD (in vivo)

		ALAS2	RABGGTB
Description		5'-aminolevulinate synthase 2	Rab geranylgeranyltransferase subunit beta
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding	Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Small GTPase Binding
	Biological Process	Response To Hypoxia Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Cellular Iron Ion Homeostasis Erythrocyte Differentiation Oxygen Homeostasis Hemoglobin Biosynthetic Process Erythrocyte Development	Cellular Protein Modification Process Visual Perception Protein Phosphopantetheinylation Protein Prenylation Protein Geranylgeranylation Regulation Of Apoptotic Process Post-translational Protein Modification
Pathways		Heme biosynthesis	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation
Drugs		Pyridoxal phosphate Glycine	N-Formylmethionine Farnesyl diphosphate Geranylgeranyl diphosphate
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)	Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)
Interacting Genes		4 interacting genes: BANP GRB2 RABGGTB SUCLA2	20 interacting genes: ALAS2 ARAF B4GALT7 CHML IGFBP6 NPSR1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A RABGGTA SH3GLB1 TAFA1 TMEM25 WDR4
Entrez ID		212	5876
HPRD ID		02356	01532
Ensembl ID		ENSG00000158578	ENSG00000137955
Uniprot IDs		P22557	A8KAJ2 P53611 Q6IB63
PDB IDs		5QQQ 5QQR 5QQS 5QQT 5QQU 5QQV 5QQW 5QQX 5QQY 5QQZ 5QR0 5QR1 5QR2 5QR3 5QR4 5QR5 5QR6 5QR7 5QR8 5QR9 5QRA 5QRB 5QRC 5QRD 5QRE 5QT3 6HRH	6J6X 6J74 6J7F 6J7X 6O60
Enriched GO Terms of Interacting Partners?
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