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TMEM31 and NSDHL
Data Source:
BioGRID
(two hybrid)
TMEM31
NSDHL
Description
transmembrane protein 31
NAD(P) dependent steroid dehydrogenase-like
Image
No pdb structure
GO Annotations
Cellular Component
Integral Component Of Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Lipid Droplet
Integral Component Of Membrane
Molecular Function
Protein Binding
C-3 Sterol Dehydrogenase (C-4 Sterol Decarboxylase) Activity
3-beta-hydroxy-delta5-steroid Dehydrogenase Activity
Protein Binding
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) Activity
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) Activity
4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) Activity
Biological Process
Hair Follicle Development
Cholesterol Biosynthetic Process
Smoothened Signaling Pathway
Cholesterol Metabolic Process
Labyrinthine Layer Blood Vessel Development
Pathways
Cholesterol biosynthesis
Drugs
NADH
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
Congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD)
GWAS
Interacting Genes
141 interacting genes:
ABHD16A
ABHD5
AGPAT4
AGTRAP
ANKRD46
APOD
ARV1
ATP5MC3
ATP6V0C
BCAP31
BLCAP
BMP10
BNIP1
BTN2A2
C14orf180
C2CD2L
CAMLG
CCL4
CGRRF1
CLDND2
CLN5
CLRN1
CMTM7
CNIH3
COX14
COX20
CTSA
CTXN3
CXCL9
CXorf66
CYB561A3
CYB5R3
DEFB103A
DEFB103B
DEFB105A
DEFB105B
DERL1
DERL3
DGAT2L6
DHRSX
DNAJC30
EBP
EHHADH
EMP1
ERG28
FAXDC2
FCER1G
FKBP8
FXYD6
GIMAP5
GJB2
GJD4
GPR151
GUCA2A
GYPA
HERPUD2
HIGD1C
HSD17B13
HSD3B7
IFITM5
ITGAM
LHFPL5
LPAR3
LRAT
LY6D
MALL
MFSD14B
MMP14
MS4A1
NAT8
NINJ1
NINJ2
NSDHL
ORMDL2
OTOP3
OTULINL
PEDS1-UBE2V1
PLN
PLP1
PLP2
PMP22
PNLIPRP1
PTPN1
RDH11
REEP2
RETREG3
RNF144A
RNF19B
RTP2
SELENOK
SELENOM
SERP2
SGTA
SLC30A8
SLC35C2
SLC35E4
SLC39A6
SLC41A1
SLC66A2
SLC7A14
SMAGP
SMIM1
SMIM3
SMPD2
SNORC
SPTSSA
STX12
STX5
SYNGR1
TEX264
TIMMDC1
TMBIM6
TMEM107
TMEM121
TMEM14A
TMEM14C
TMEM182
TMEM203
TMEM208
TMEM218
TMEM239
TMEM242
TMEM254
TMEM255B
TMEM44
TMEM50A
TMEM86A
TMX2
TNFRSF10B
TRARG1
TSPAN2
TVP23B
UBE2J1
UBQLN1
UBQLN2
VAMP2
VAMP3
VAMP5
YIF1A
YIPF6
ZFPL1
4 interacting genes:
GPR35
RHBDD1
TMEM31
TMX2
Entrez ID
203562
50814
HPRD ID
06652
02229
Ensembl ID
ENSG00000179363
ENSG00000147383
Uniprot IDs
A0A140VK58
Q5JXX7
A0A384NPZ7
Q15738
PDB IDs
6JKG
6JKH
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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