C9orf72 and POP7

Data Source:
BioGRID (two hybrid)

		C9orf72	POP7
Description		C9orf72-SMCR8 complex subunit	POP7 homolog, ribonuclease P/MRP subunit
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GO Annotations	Cellular Component	P-body Extracellular Space Nucleus Cytoplasm Lysosome Endosome Autophagosome Cytosol Cytoplasmic Stress Granule Dendrite Nuclear Membrane Guanyl-nucleotide Exchange Factor Complex Perikaryon Intracellular Membrane-bounded Organelle Axonal Growth Cone Main Axon Flemming Body Atg1/ULK1 Kinase Complex	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Multimeric Ribonuclease P Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Endocytosis Autophagy Regulation Of Autophagy Positive Regulation Of Macroautophagy Stress Granule Assembly Axon Extension Regulation Of Catalytic Activity Regulation Of Actin Filament Organization Late Endosome To Lysosome Transport Regulation Of TORC1 Signaling Regulation Of Autophagosome Assembly	TRNA 5'-leader Removal RRNA Processing TRNA Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways			tRNA processing in the nucleus
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 30976013 25442119 29566793 22959728 27455348 19734901 20801718 24931836) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Delirium ( 29631748) Metabolite levels ( 23823483) PCA3 expression level ( 23555189)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Low density lipoprotein cholesterol levels ( 32154731) Medication use (thyroid preparations) ( 31015401) Pursuit maintenance gain in psychotic disorders ( 29064472) Red blood cell count ( 32888494 27863252) Schizophrenia ( 30285260)
Interacting Genes		14 interacting genes: APP COIL CRX EIF2B2 HMG20A NMI POP7 REL SMCR8 SMN1 SRPK1 SYN3 TRIM73 VRTN	9 interacting genes: APP C9orf72 HSPB1 LAGE3 RPP25 RPP25L RPP38 RPP40 SMN1
Entrez ID		203228	10248
HPRD ID		12975	09357
Ensembl ID		ENSG00000147894	ENSG00000172336
Uniprot IDs		Q96LT7	O75817
PDB IDs		6LT0 6V4U	6AHR 6AHU 6CWX
Enriched GO Terms of Interacting Partners?
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