POP7 and RPP40

Data Source:
HPRD (in vivo)

		POP7	RPP40
Description		POP7 homolog, ribonuclease P/MRP subunit	ribonuclease P/MRP subunit p40
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GO Annotations	Cellular Component	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Multimeric Ribonuclease P Complex Intracellular Membrane-bounded Organelle	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Multimeric Ribonuclease P Complex
	Molecular Function	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding	Ribonuclease MRP Activity Ribonuclease P Activity Ribonuclease P RNA Binding
	Biological Process	TRNA 5'-leader Removal RRNA Processing TRNA Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA 5'-leader Removal Endonucleolytic Cleavage Involved In TRNA Processing
Pathways		tRNA processing in the nucleus	tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Low density lipoprotein cholesterol levels ( 32154731) Medication use (thyroid preparations) ( 31015401) Pursuit maintenance gain in psychotic disorders ( 29064472) Red blood cell count ( 32888494 27863252) Schizophrenia ( 30285260)
Interacting Genes		9 interacting genes: APP C9orf72 HSPB1 LAGE3 RPP25 RPP25L RPP38 RPP40 SMN1	8 interacting genes: MEOX2 POP1 POP7 PTEN RPP14 RPP21 RPP30 RPP38
Entrez ID		10248	10799
HPRD ID		09357	09361
Ensembl ID		ENSG00000172336	ENSG00000124787
Uniprot IDs		O75817	A0A087X1N3 O75818
PDB IDs		6AHR 6AHU 6CWX	6AHR 6AHU 6AHV
Enriched GO Terms of Interacting Partners?
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