C9orf72 and VRTN

Data Source:
BioGRID (two hybrid)

		C9orf72	VRTN
Description		C9orf72-SMCR8 complex subunit	vertebrae development associated
Image			No pdb structure
GO Annotations	Cellular Component	P-body Extracellular Space Nucleus Cytoplasm Lysosome Endosome Autophagosome Cytosol Cytoplasmic Stress Granule Dendrite Nuclear Membrane Guanyl-nucleotide Exchange Factor Complex Perikaryon Intracellular Membrane-bounded Organelle Axonal Growth Cone Main Axon Flemming Body Atg1/ULK1 Kinase Complex	Chromatin
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding	Transposase Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Endocytosis Autophagy Regulation Of Autophagy Positive Regulation Of Macroautophagy Stress Granule Assembly Axon Extension Regulation Of Catalytic Activity Regulation Of Actin Filament Organization Late Endosome To Lysosome Transport Regulation Of TORC1 Signaling Regulation Of Autophagosome Assembly	Transposition, DNA-mediated Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 30976013 25442119 29566793 22959728 27455348 19734901 20801718 24931836) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Delirium ( 29631748) Metabolite levels ( 23823483) PCA3 expression level ( 23555189)	FEV1 ( 30804560) Lung function (FVC) ( 30804560) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: APP COIL CRX EIF2B2 HMG20A NMI POP7 REL SMCR8 SMN1 SRPK1 SYN3 TRIM73 VRTN	10 interacting genes: C9orf72 CTBP2 EIF4A3 FAM90A1 POLR3C RAB2B RAB3A RAB3B RAB3C RAB3D
Entrez ID		203228	55237
HPRD ID		12975	16593
Ensembl ID		ENSG00000147894	ENSG00000133980
Uniprot IDs		Q96LT7	Q9H8Y1
PDB IDs		6LT0 6V4U
Enriched GO Terms of Interacting Partners?
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