UNC13D and RAB27A

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		UNC13D	RAB27A
Description		unc-13 homolog D	RAB27A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Late Endosome Cytosol Membrane Weibel-Palade Body Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Recycling Endosome Exocytic Vesicle	Photoreceptor Outer Segment Extracellular Region Lysosome Late Endosome Golgi Apparatus Cytosol Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle
	Molecular Function	Protein Binding Small GTPase Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Granuloma Formation Germinal Center Formation Phagocytosis Regulation Of Mast Cell Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Defense Response To Virus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Regulated Secretory Pathway	Protein Targeting Exocytosis Blood Coagulation Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Multivesicular Body Organization Neutrophil Degranulation Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways		Neutrophil degranulation	Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency	Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Eosinophil counts ( 27863252) Major depressive disorder ( 27777418) Red cell distribution width ( 32888494) Systolic blood pressure ( 30578418) White matter hyperintensity burden ( 25663218)	Fractional exhaled nitric oxide levels ( 25431337) Glioma ( 30714141)
Interacting Genes		3 interacting genes: LMNA RAB27A RAB27B	28 interacting genes: ADRB2 APP CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		201294	5873
HPRD ID		10598	04845
Ensembl ID		ENSG00000092929	ENSG00000069974
Uniprot IDs		Q70J99	A2RU94 P51159
PDB IDs			6HUF
Enriched GO Terms of Interacting Partners?
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