MARK2 and GSK3B

Data Source:
HPRD (in vitro)

		MARK2	GSK3B
Description		microtubule affinity regulating kinase 2	glycogen synthase kinase 3 beta
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Microtubule Bundle	Nucleus Nucleoplasm Cytoplasm Mitochondrion Centrosome Cytosol Plasma Membrane Axon Dendrite Beta-catenin Destruction Complex Postsynapse Glutamatergic Synapse Wnt Signalosome
	Molecular Function	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Cadherin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Transcription Factor Binding Protease Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Beta-catenin Binding Kinase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding Dynactin Binding Tau Protein Binding Tau-protein Kinase Activity NF-kappaB Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Microtubule Binding	Epithelial To Mesenchymal Transition Positive Regulation Of Cell-matrix Adhesion Glycogen Metabolic Process Protein Phosphorylation ER Overload Response Signal Transduction Dopamine Receptor Signaling Pathway Circadian Rhythm Insulin Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Mitochondrion Organization Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Hippocampus Development Establishment Of Cell Polarity Maintenance Of Cell Polarity Regulation Of Axon Extension Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Microtubule-based Process Intracellular Signal Transduction Cellular Response To Interleukin-3 Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Protein Autophosphorylation Positive Regulation Of Protein Export From Nucleus Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Excitatory Postsynaptic Potential Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Superior Temporal Gyrus Development Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Projection Organization Regulation Of Microtubule Anchoring At Centrosome Regulation Of Cellular Response To Heat Negative Regulation Of Protein Localization To Nucleus Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Neuron Death Positive Regulation Of Neuron Death Negative Regulation Of Protein Acetylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Dopaminergic Neuron Differentiation Cellular Response To Amyloid-beta Positive Regulation Of Protein Localization To Centrosome Beta-catenin Destruction Complex Assembly Beta-catenin Destruction Complex Disassembly Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Glycogen (starch) Synthase Activity
Pathways			Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade AKT phosphorylates targets in the cytosol Regulation of HSF1-mediated heat shock response CRMPs in Sema3A signaling Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane B-WICH complex positively regulates rRNA expression Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Constitutive Signaling by AKT1 E17K in Cancer Ubiquitin-dependent degradation of Cyclin D Regulation of RUNX2 expression and activity Replication of the SARS-CoV-1 genome Maturation of nucleoprotein Maturation of nucleoprotein Maturation of nucleoprotein Replication of the SARS-CoV-2 genome
Drugs		Fostamatinib	Lithium cation 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione SB-409513 AR-AO-14418 Staurosporine Indirubin-3'-monoxime 6-bromoindirubin-3'-oxime Alsterpaullone Phosphoaminophosphonic Acid-Adenylate Ester 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE Fostamatinib Tideglusib Lithium citrate Lithium succinate Lithium carbonate
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)	HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		32 interacting genes: BAIAP2 CAMK1 CASK DVL3 FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MAPT MTCL1 NEDD4 NEDD4L PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 STK4 UTRN YWHAB YWHAQ YWHAZ	225 interacting genes: ACLY ACSBG1 ACTL6B ADAP1 ADIRF AKAP11 AKT1 AKT2 AKT3 APC APP AR ARRB1 ASRGL1 ATP5IF1 ATXN3 AURKA AXIN1 AXIN2 BAG6 BCL2A1 BCL2L1 BCL3 BEX1 BHLHE41 BICD1 BICD2 BRIX1 BTRC BZW2 CABYR CAMSAP3 CCND1 CCNE1 CDH1 CDK5 CDX2 CEBPA CEBPD CEBPZ CENPB CHD3 CIITA CLEC3B CREB1 CREB3L3 CREM CSAD CSNK2B CST6 CTNNB1 CTNND1 DBI DCTN1 DCTN2 DCTN3 DDIT4 DEAF1 DEFA1 DELEC1 DHX34 DISC1 DNAJC13 DNM1L DNMT1 DNMT3L DPYSL2 DUSP9 DYNC1I1 E2F1 EEF1G EFTUD2 EIF2B5 EIF4EBP1 ENTPD6 ERG28 EYA1 FAM193B FAM83D FBN3 FBXO7 FBXW11 FEN1 FIBP FKBP14 FOXO1 FRAT1 FRAT2 FZD5 GBP2 GFI1 GIPC1 GJB5 GNB2 GPR39 GYS1 HDAC4 HNRNPD HSP90AA1 HSPA4 IGHM IGSF21 IKBKG ILK IQCG IRF1 JUN KDM1A KHSRP KIAA1191 KIF5B KLF2 KLF5 LMO4 LPCAT1 LRP6 LUC7L2 MAP1B MAP3K1 MAP3K4 MAP4 MAPK1 MAPT MARK2 MASP1 MCL1 MDM2 MED24 MICAL1 MID1IP1 MITF MPP1 MTF2 MTOR MUC1 MYC MYOCD NAT9 NBR1 NCOA3 NDRG1 NFE2L1 NFE2L2 NFE2L3 NFKB1 NIN NOTCH1 NOTCH2 NRBP1 NSFL1C OGA OGT PDE4D PFKFB4 PHLPP1 PIAS1 PIM2 PMAIP1 PPARGC1A PPP1R2 PRKACA PRKCA PRKCB PRKCZ PRKDC PSEN1 PTK2 PTN PTPN1 PXN QARS1 RAI1 RBPJ RCAN1 RELB RICTOR RPL36AL RPLP1 RPS2 RPS6KA1 RSU1 RXRA SAP30BP SGK1 SGK3 SLA SMAD3 SNAI1 SNCA SNCAIP SOX10 SPTBN4 SREBF1 STAT2 SYNE4 TAZ TLE1 TMEM132A TMEM44 TNFAIP3 TONSL TP53 TPPP TRAF6 TSC2 TUBA1A UBE2D1 UBR1 UBR5 UBXN6 UFM1 UPF3A VIM VPS51 WSB1 XIAP XPNPEP1 YBX1 YBX3 YWHAZ ZFPM1 ZHX1 ZNF135 ZNF227 ZNF746
Entrez ID		2011	2932
HPRD ID		02753	05418
Ensembl ID		ENSG00000072518	ENSG00000082701
Uniprot IDs		A0A140VJP1 A8K2S4 Q7KZI7	P49841 Q6FI27
PDB IDs		3IEC 5EAK 5KZ7 5KZ8	1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2O5K 2OW3 2UW9 2X39 2XH5 3CQU 3CQW 3DU8 3E87 3E88 3E8D 3F7Z 3F88 3GB2 3I4B 3L1S 3M1S 3MV5 3OW4 3PUP 3Q3B 3QKK 3SAY 3SD0 3ZDI 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4ACH 4AFJ 4B7T 4DIT 4EKK 4IQ6 4J1R 4J71 4NM0 4NM3 4NM5 4NM7 4PTC 4PTE 4PTG 5F94 5F95 5HLN 5HLP 5K5N 5KPK 5KPL 5KPM 5OY4 5T31 6B8J 6BUU 6GJO 6GN1 6H0U 6HK3 6HK4 6HK7 6NPZ 6TCU 6V6L 6Y9R 6Y9S
Enriched GO Terms of Interacting Partners?
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