MARK2 and UTRN

Data Source:
BioGRID (pull down, enzymatic study)

		MARK2	UTRN
Description		microtubule affinity regulating kinase 2	utrophin
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Microtubule Bundle	Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Membrane Filopodium Growth Cone Cortical Actin Cytoskeleton Filopodium Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Postsynaptic Membrane Extracellular Exosome Contractile Ring
	Molecular Function	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Cadherin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Actin Binding Integrin Binding Protein Binding Zinc Ion Binding Vinculin Binding Protein Kinase Binding Actin Filament Binding
	Biological Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Microtubule Binding	Positive Regulation Of Cell-matrix Adhesion Muscle Contraction Muscle Organ Development Neuromuscular Junction Development Response To Denervation Involved In Regulation Of Muscle Adaptation Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Fostamatinib	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)	Loneliness (multivariate analysis) ( 27629369) Multisite chronic pain ( 31194737) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Refractive error ( 32231278) Remission after SSRI treatment in MDD or openness ( 29559929) Response to fenofibrate (triglyceride levels) ( 27002377) Response to mepolizumab in severe asthma ( 29229094) Response to SSRI in MDD or openness ( 29559929)
Interacting Genes		32 interacting genes: BAIAP2 CAMK1 CASK DVL3 FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MAPT MTCL1 NEDD4 NEDD4L PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 STK4 UTRN YWHAB YWHAQ YWHAZ	20 interacting genes: ACTA1 ACTN2 C1QTNF9 CALM1 DAG1 DISC1 DMD DRP2 DTNA DTNB ITGB1BP1 MARCHF5 MARK2 PGM5 PTEN PTPN12 SASH1 SNTA1 SNTB1 SNTB2
Entrez ID		2011	7402
HPRD ID		02753	00547
Ensembl ID		ENSG00000072518	ENSG00000152818
Uniprot IDs		A0A140VJP1 A8K2S4 Q7KZI7	P46939 Q6LBS5
PDB IDs		3IEC 5EAK 5KZ7 5KZ8	1BHD 1QAG 6M5G
Enriched GO Terms of Interacting Partners?
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