PIKFYVE and MIR140

Data Source:
BioGRID (unspecified method)

		PIKFYVE	MIR140
Description		phosphoinositide kinase, FYVE-type zinc finger containing	microRNA 140
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytosol Cell-cell Junction Endosome Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle Membrane Raft Perinuclear Region Of Cytoplasm	Extracellular Space
	Molecular Function	1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity 1-phosphatidylinositol-5-kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Complex Binding MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Protein Targeting To Membrane Phosphatidylinositol Biosynthetic Process Receptor-mediated Endocytosis Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neutrophil Chemotaxis Myelin Assembly Melanosome Organization Protein Localization To Nucleus Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Peptidyl-serine Autophosphorylation Retrograde Transport, Endosome To Golgi Phosphatidylinositol Phosphorylation Phagosome Maturation Phagosome-lysosome Fusion 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Phosphatidylinositol 5-phosphate Metabolic Process Regulation Of Autophagosome Assembly	Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of BMP Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Gene Silencing By MiRNA Defense Response To Bacterium Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Vascular Endothelial Growth Factor Production Cellular Response To Amyloid-beta Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases		Fleck corneal dystrophy (FCD); Francois-Neetens speckled corneal dystrophy
GWAS		Adult asthma ( 27611488) Post bronchodilator FEV1 ( 26634245)	Body mass index ( 26426971)
Interacting Genes		6 interacting genes: APP CDK5 H3C1 MIR140 RABEPK VAC14	68 interacting genes: ADARB1 AIMP1 APOBEC3B C1QBP CELF1 CELF2 CRTAP CSTF1 DARS1 DDX1 DDX21 DDX3X DDX49 EIF2AK2 EPRS1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC MARS1 MATR3 NOL6 NONO NUDT21 PDCD11 PIKFYVE PIP5K1A PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RTCB SF3B1 SF3B3 SFPQ SYNCRIP TAF15 TRA2A TRA2B UPF1 UTP20 YBX1 YBX3
Entrez ID		200576	406932
HPRD ID		17852
Ensembl ID		ENSG00000115020	ENSG00000208017
Uniprot IDs		Q9Y2I7
PDB IDs		7K2V
Enriched GO Terms of Interacting Partners?
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