PIKFYVE and CDK5

Data Source:
BioGRID (enzymatic study)

		PIKFYVE	CDK5
Description		phosphoinositide kinase, FYVE-type zinc finger containing	cyclin dependent kinase 5
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GO Annotations	Cellular Component	Golgi Membrane Cytosol Cell-cell Junction Endosome Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle Membrane Raft Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Lamellipodium Cell Junction Filopodium Axon Dendrite Growth Cone Neuromuscular Junction Neuron Projection Neuronal Cell Body Perikaryon Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse
	Molecular Function	1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity 1-phosphatidylinositol-5-kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ErbB-2 Class Receptor Binding Protein Binding ATP Binding Microtubule Binding Kinase Activity Protein Kinase Binding Acetylcholine Receptor Activator Activity ErbB-3 Class Receptor Binding Ephrin Receptor Binding Tau Protein Binding Tau-protein Kinase Activity Hsp90 Protein Binding Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Targeting To Membrane Phosphatidylinositol Biosynthetic Process Receptor-mediated Endocytosis Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neutrophil Chemotaxis Myelin Assembly Melanosome Organization Protein Localization To Nucleus Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Peptidyl-serine Autophosphorylation Retrograde Transport, Endosome To Golgi Phosphatidylinositol Phosphorylation Phagosome Maturation Phagosome-lysosome Fusion 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Phosphatidylinositol 5-phosphate Metabolic Process Regulation Of Autophagosome Assembly	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Neuron Migration Synaptic Transmission, Dopaminergic Protein Phosphorylation Intracellular Protein Transport Nucleocytoplasmic Transport Mitochondrion Organization Cell-matrix Adhesion Chemical Synaptic Transmission Axonogenesis Synapse Assembly Skeletal Muscle Tissue Development Motor Neuron Axon Guidance Visual Learning Response To Wounding Schwann Cell Development Synaptic Vesicle Exocytosis Regulation Of Macroautophagy Phosphorylation Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sensory Perception Of Pain Cerebellar Cortex Formation Hippocampus Development Layer Formation In Cerebral Cortex Central Nervous System Neuron Development Corpus Callosum Development Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Axon Extension Cortical Actin Cytoskeleton Organization Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Synaptic Plasticity Positive Regulation Of Protein Binding Receptor Catabolic Process Positive Regulation Of Glial Cell Apoptotic Process Synaptic Transmission, Glutamatergic Protein Localization To Synapse Serine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Autophosphorylation Negative Regulation Of Protein Export From Nucleus Behavioral Response To Cocaine Regulation Of Synaptic Plasticity Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Rhythmic Process Axon Extension Oligodendrocyte Differentiation Dendrite Morphogenesis Cell Division Neuron Apoptotic Process Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Regulation Of Dendritic Spine Morphogenesis Calcium Ion Import Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Targeting To Membrane Synapse Pruning Regulation Of Neurotransmitter Receptor Activity Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Neuron Death Positive Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Localization To Plasma Membrane Regulation Of Synaptic Vesicle Recycling Cellular Response To Amyloid-beta Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane	DARPP-32 events CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription Activated NTRK2 signals through CDK5 Factors involved in megakaryocyte development and platelet production
Drugs			Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases		Fleck corneal dystrophy (FCD); Francois-Neetens speckled corneal dystrophy
GWAS		Adult asthma ( 27611488) Post bronchodilator FEV1 ( 26634245)	Eyebrow thickness ( 26926045) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		6 interacting genes: APP CDK5 H3C1 MIR140 RABEPK VAC14	81 interacting genes: AATK ABL1 ACTN1 ALAS1 AMPH APP BAG6 CABLES1 CABLES2 CCND2 CCND3 CCNG1 CCNI CDC25A CDC25B CDC25C CDC37 CDK16 CDK5R1 CDK5R2 CDK5RAP1 CDK5RAP2 CDKN1B CHN1 CSNK1D DAB1 DCX DNM1 ERBB3 EZR FSD1 FYN FZR1 GAK GRIN2A GSK3B H1-0 H1-1 H1-5 HTRA2 KIF26B LMTK2 MAP2K1 MAPK10 MAPT MAST1 MBP MEF2A MEOX2 MIR9-1HG NDEL1 NEDD4 NEDD4L NES PAK1 PCNA PIKFYVE PIP5K1C PPARG PPP1R1B PPP1R2 PRKN PSEN1 PTPN2 PURA RB1 RNF32 RPL34 SET SPDYA SPDYE4 SRC STX1A STXBP1 SYN1 SYNJ1 TLN1 TP53 TRIM59 WASF1 YBX3
Entrez ID		200576	1020
HPRD ID		17852	00449
Ensembl ID		ENSG00000115020	ENSG00000164885
Uniprot IDs		Q9Y2I7	A0A090N7W4 A0A0S2Z355 Q00535
PDB IDs		7K2V	1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8
Enriched GO Terms of Interacting Partners?
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