PIKFYVE and RABEPK

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PIKFYVE	RABEPK
Description		phosphoinositide kinase, FYVE-type zinc finger containing	Rab9 effector protein with kelch motifs
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytosol Cell-cell Junction Endosome Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle Membrane Raft Perinuclear Region Of Cytoplasm	Endosome Cytosol Endosome Membrane Transport Vesicle Trans-Golgi Network Membrane
	Molecular Function	1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity 1-phosphatidylinositol-5-kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding
	Biological Process	Protein Targeting To Membrane Phosphatidylinositol Biosynthetic Process Receptor-mediated Endocytosis Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neutrophil Chemotaxis Myelin Assembly Melanosome Organization Protein Localization To Nucleus Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Peptidyl-serine Autophosphorylation Retrograde Transport, Endosome To Golgi Phosphatidylinositol Phosphorylation Phagosome Maturation Phagosome-lysosome Fusion 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Phosphatidylinositol 5-phosphate Metabolic Process Regulation Of Autophagosome Assembly	Receptor-mediated Endocytosis Vesicle Docking Involved In Exocytosis
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases		Fleck corneal dystrophy (FCD); Francois-Neetens speckled corneal dystrophy
GWAS		Adult asthma ( 27611488) Post bronchodilator FEV1 ( 26634245)	Refractive error ( 32231278)
Interacting Genes		6 interacting genes: APP CDK5 H3C1 MIR140 RABEPK VAC14	8 interacting genes: GLUL PIKFYVE POR PRKRA RAB9A TMEM98 TRIM55 ZYX
Entrez ID		200576	10244
HPRD ID		17852	09337
Ensembl ID		ENSG00000115020	ENSG00000136933
Uniprot IDs		Q9Y2I7	A0A024R8A0 A0A0S2Z4Z1 A0A0S2Z4Z5 Q7Z6M1
PDB IDs		7K2V
Enriched GO Terms of Interacting Partners?
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