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HSPA5 and METTL21A
Data Source:
BioGRID
(enzymatic study)
HSPA5
METTL21A
Description
heat shock protein family A (Hsp70) member 5
methyltransferase like 21A
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Cell Surface
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Midbody
Protein-containing Complex
Endoplasmic Reticulum Chaperone Complex
Melanosome
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Molecular Function
Calcium Ion Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
Protein Domain Specific Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ribosome Binding
Protein Folding Chaperone
Cadherin Binding
Unfolded Protein Binding
Chaperone Binding
Misfolded Protein Binding
Protein Binding
Protein Methyltransferase Activity
Protein-lysine N-methyltransferase Activity
Hsp70 Protein Binding
Heat Shock Protein Binding
ATPase Binding
Biological Process
Luteolysis
ER Overload Response
Positive Regulation Of Neuron Projection Development
Cerebellum Structural Organization
Cerebellar Purkinje Cell Layer Development
Substantia Nigra Development
Neuron Differentiation
Positive Regulation Of Cell Migration
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Posttranslational Protein Targeting To Membrane, Translocation
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein Ubiquitination
Cellular Response To Unfolded Protein
Protein Folding In Endoplasmic Reticulum
Maintenance Of Protein Localization In Endoplasmic Reticulum
Cellular Response To Drug
IRE1-mediated Unfolded Protein Response
PERK-mediated Unfolded Protein Response
ATF6-mediated Unfolded Protein Response
Protein Refolding
Cellular Response To Glucose Starvation
Response To Cocaine
Negative Regulation Of Apoptotic Process
Chaperone Cofactor-dependent Protein Refolding
Neuron Apoptotic Process
Regulation Of Protein Folding In Endoplasmic Reticulum
Cellular Response To Antibiotic
Cellular Response To Calcium Ion
Cellular Response To Manganese Ion
Cellular Response To CAMP
Cellular Response To Interleukin-4
Cellular Response To Gamma Radiation
Stress Response To Metal Ion
Toxin Transport
Regulation Of ATF6-mediated Unfolded Protein Response
Regulation Of IRE1-mediated Unfolded Protein Response
Negative Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of PERK-mediated Unfolded Protein Response
Response To Methamphetamine Hydrochloride
Cellular Response To Nerve Growth Factor Stimulus
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Protein Methylation
Peptidyl-lysine Methylation
Regulation Of ATPase Activity
Pathways
Platelet degranulation
Regulation of HSF1-mediated heat shock response
ATF6 (ATF6-alpha) activates chaperones
PERK regulates gene expression
IRE1alpha activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Protein methylation
Drugs
Antihemophilic factor, human recombinant
Acetylsalicylic acid
Copper
Lonoctocog alfa
Moroctocog alfa
Diseases
GWAS
Refractive error (
32231278
)
HDL cholesterol levels (
32203549
)
Opioid sensitivity (
23183491
)
Systolic blood pressure (
28135244
28739976
30578418
)
Interacting Genes
70 interacting genes:
A2M
APC
APOB
BAG3
BCAR1
CASP7
CPT1A
DDX24
DNAJC1
DNAJC10
DNAJC3
DPH1
DPYSL5
EIF2AK3
ERBB2
ERCC6
ERN1
ERP29
F8
FCHSD2
GRB2
GRIA1
HLA-C
HMGB1
HSPB1
HSPBP1
HTR3A
IGHM
KRT14
KRT18
KRT8
LCT
LDLR
LINC01554
MATK
METTL21A
MTNR1A
MTNR1B
NDRG1
OTUD3
PARK7
PAWR
PCSK7
PRNP
PSME3
PTPN11
PTPRF
RPN1
SEC61A1
SEC63
SERPINB5
SH3BP4
SIL1
SIRPA
SQSTM1
SREBF2
STMN1
SUMO2
SUMO4
TCERG1
TG
TMEM132A
TMEM62
TRA
TSHR
UBE3A
UBQLN4
VHL
VWF
YWHAB
15 interacting genes:
ARPC4
ATRIP
HSPA1A
HSPA5
HSPA8
LNX1
LZTS1
MEI4
MEOX2
MSRB3
PFDN5
ZBED8
ZNF620
ZNF655
ZRANB1
Entrez ID
3309
151194
HPRD ID
00682
14090
Ensembl ID
ENSG00000044574
ENSG00000144401
Uniprot IDs
P11021
V9HWB4
C9JES0
H7BXH9
Q8WXB1
PDB IDs
3IUC
3LDL
3LDN
3LDO
3LDP
5E84
5E85
5E86
5EVZ
5EX5
5EXW
5EY4
5F0X
5F1X
5F2R
6ASY
6CZ1
6DFM
6DFO
6DO2
6DWS
4LEC
Enriched GO Terms of Interacting Partners
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