HSPB1 and ANXA1

Data Source:
BioGRID (two hybrid)

		HSPB1	ANXA1
Description		heat shock protein family B (small) member 1	annexin A1
Image
GO Annotations	Cellular Component	Proteasome Complex Extracellular Space Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Focal Adhesion Extracellular Exosome Axon Cytoplasm	Cornified Envelope Phagocytic Cup Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Actin Filament Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane Extrinsic Component Of External Side Of Plasma Membrane Extrinsic Component Of Endosome Membrane Motile Cilium Early Endosome Membrane Mitochondrial Membrane Vesicle Protein-containing Complex Sarcolemma Mast Cell Granule Collagen-containing Extracellular Matrix Extracellular Exosome Synaptic Membrane
	Molecular Function	RNA Binding Protein Kinase C Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Protein Folding Chaperone RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Single-stranded DNA Binding Single-stranded RNA Binding Signaling Receptor Binding Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Double-stranded DNA Helicase Activity Identical Protein Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion DNA/DNA Annealing Activity
	Biological Process	Retina Homeostasis Regulation Of Protein Phosphorylation Regulation Of Translational Initiation Negative Regulation Of Protein Kinase Activity Response To Unfolded Protein Response To Virus Regulation Of Autophagy Viral Process Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of MRNA Stability Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Chaperone-mediated Protein Folding Platelet Aggregation Negative Regulation Of Protein Serine/threonine Kinase Activity Anterograde Axonal Protein Transport Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis	Neutrophil Homeostasis Adaptive Immune Response Monocyte Chemotaxis Regulation Of Leukocyte Migration Phagocytosis Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cell Shape Response To X-ray Myoblast Migration Involved In Skeletal Muscle Regeneration Peptide Cross-linking Cytokine-mediated Signaling Pathway Insulin Secretion Keratinocyte Differentiation Prostate Gland Development Endocrine Pancreas Development Positive Regulation Of Vesicle Fusion Positive Regulation Of Prostaglandin Biosynthetic Process Actin Cytoskeleton Reorganization Response To Estradiol DNA Duplex Unwinding Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Neutrophil Apoptotic Process Cellular Response To Vascular Endothelial Growth Factor Stimulus Gliogenesis Positive Regulation Of T Cell Proliferation Response To Drug Negative Regulation Of Apoptotic Process Response To Peptide Hormone Estrous Cycle Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Exocytosis Alpha-beta T Cell Differentiation Regulation Of Hormone Secretion Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Regulation Of Inflammatory Response Cellular Response To Hydrogen Peroxide Hepatocyte Differentiation Prolactin Secretion Response To Interleukin-1 Cellular Response To Glucocorticoid Stimulus Granulocyte Chemotaxis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Wound Healing Neutrophil Clearance Cell-cell Adhesion Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phospholipase A2 Activity
Pathways		VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Smooth Muscle Contraction Interleukin-4 and Interleukin-13 signaling
Drugs		Apatorsen Artenimol Phenethyl Isothiocyanate	Amcinonide Fluocinolone acetonide Hydrocortisone Methylprednisolone Clobetasol propionate Budesonide Dexamethasone Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate Prednisolone phosphate Dexamethasone acetate Betamethasone phosphate
Diseases		Distal hereditary motor neuropathies (dHMN)
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Schizophrenia ( 30285260)	Blood protein levels ( 28240269) Chronotype ( 30696823) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Urate levels in obese individuals ( 25811787)
Interacting Genes		254 interacting genes: ACAP2 ACBD6 ACTC1 ACTN1 ACTN2 ACTN4 ADCY9 ADD3 ADPRS AGAP10P AGAP3 AGAP4 AGAP5 AGAP7P AKT1 ALPI AMD1 ANAPC7 ANK1 ANKRD7 ANXA1 AP2B1 APPL1 ARHGAP28 ARHGEF7 ARIH1 ARMT1 ARRDC5 ATXN10 BAG3 BICDL1 BVES C11orf98 C2orf73 CAMK1 CBX1 CCDC32 CCDC70 CCHCR1 CCNC CCNDBP1 CCNO CDC123 CDK5RAP3 CENPK CEP78 CETN3 CFAP251 CLCN3 CPSF3 CRNKL1 CRYAA CRYAB CRYBB2 CRYGC CS CYCS DAXX DES DMAP1 DNAJC21 ECPAS EHD1 EIF1AX EIF2S1 EIF3M EIF4G1 EIF4G3 EIF5 ENPP2 EPB41L1 EPB41L2 EPB41L3 ERCC5 ERICH6 ESR1 FAM71D FLNB FXR1 GAPVD1 GDI2 GLMN GNPAT GOLGA8A GRIPAP1 GRK3 GSTO1 GTSF1 GUCA1A HAUS8 HDLBP HECTD1 HNRNPA2B1 HNRNPD HNRNPF HNRNPU HSP90AB1 HSPA4 HSPA5 HSPB8 HUWE1 IARS2 IGBP1 IGSF21 INPP5K INS ISG20L2 KANSL1 KCMF1 KCTD3 KLC1 KNSTRN KPNA3 KRT18 KRT72 LBP LIG1 LONRF1 LRIF1 LSM3 LUZP1 MAPK14 MAPKAPK2 MAPKAPK3 MAPKAPK5 MAPT MCM6 MDH2 MED31 MFAP1 MPHOSPH6 MRGBP MRPL28 MRPL40 MRPS23 MSL1 MTIF2 MYG1 MYL12A MYL12B MYL9 MYLK NAP1L1 NAPA NBAS NCKIPSD NEK10 NEXN NFKBIA NFU1 NSMCE4A NVL OBSL1 OPTN OSBPL9 PAF1 PALM3 PELO PGM2 PHYHIPL PLG PNISR PNPT1 POP7 PPA1 PPM1A PPP2R3C PRPF19 PRPF40A PSMA3 PSMA6 PSMB2 PSMC1 PSMD1 PTGES3 PTPN3 PTPRA RAB41 RAD23A RALA RASSF9 RBM25 RBM39 RBM48 RBPJ RPAP3 RPSA RSPH3 RYBP S100A4 SAT1 SBF1 SEC13 SERTAD1 SF3A3 SF3B3 SLC7A9 SMARCA2 SMARCA4 SMARCD1 SNRNP200 SNRPF SPACA7 SPATA7 SPIN1 SPTBN1 SQSTM1 SRP72 STUB1 SUMO2 SUPT5H SYCE1 TARBP2 TARS1 TBC1D1 TBC1D3B TGFB1I1 TGM1 THOC5 TJP2 TMCO3 TOMM70 TOX4 TP53 TPT1 TRIM24 TRIM54 TRIM55 TRIM63 TSNAXIP1 TTC3 TTC39C TXNL1 UCHL5 UFD1 UQCC2 UQCRB VIM WASHC3 WDR83 WWP1 XPO1 XRCC5 YWHAB YWHAE YWHAH YWHAQ YWHAZ ZBTB17 ZBTB37 ZFAT ZNF131 ZNF197 ZNRF3	34 interacting genes: APBB1 CCT7 COPS6 CSAD CZIB DYSF EGFR ERG28 FAF1 FPR1 GAPDH HMGA1 HSPB1 KLHL23 KMT2B KRT8 LNPK LRIF1 MEIS2 OTUB1 PRKCI RPA1 S100A11 SRC SUMO2 TGM2 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UNC119 USP7 YWHAQ
Entrez ID		3315	301
HPRD ID		09076	01060
Ensembl ID		ENSG00000106211	ENSG00000135046
Uniprot IDs		P04792 V9HW43	P04083 Q5TZZ9
PDB IDs		2N3J 3Q9P 3Q9Q 4MJH 6DV5 6GJH	1AIN 1BO9 1QLS 5VFW
Enriched GO Terms of Interacting Partners?
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