EIF4A1 and MYH10

Data Source:
BioGRID (biochemical)

		EIF4A1	MYH10
Description		eukaryotic translation initiation factor 4A1	myosin heavy chain 10
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Exosome	Stress Fiber Nucleus Cytoplasm Cytosol Polysome Cell Cortex Myosin Complex Myosin II Complex Lamellipodium Midbody Cleavage Furrow Actomyosin Extracellular Exosome Myosin II Filament
	Molecular Function	RNA Cap Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding	Microfilament Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity RNA Stem-loop Binding ADP Binding MRNA 5'-UTR Binding Actin Filament Binding
	Biological Process	Cytoplasmic Translational Initiation Translational Initiation Viral Process	Mitotic Cytokinesis Cell Adhesion Regulation Of Cell Shape Actin Filament-based Movement Actomyosin Structure Organization Positive Regulation Of Protein Secretion Modification Of Postsynaptic Actin Cytoskeleton
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs		Copper
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Type 2 diabetes ( 30130595)
Interacting Genes		13 interacting genes: EIF4G1 EIF4G2 EIF4G3 FAM107A LIG4 MAPK6 PAIP1 PLPPR4 PRMT1 SUMO2 TNKS UCHL5 UPF2	11 interacting genes: APC BCAP31 DUX4 ECPAS MYH9 PBX1 PTEN S100A4 YWHAE YWHAG ZNF512B
Entrez ID		1973	4628
HPRD ID		04030	01178
Ensembl ID		ENSG00000161960	ENSG00000133026
Uniprot IDs		P60842	G1UI33 P35580
PDB IDs		2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW	4PD3
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?