DTX3 and UBASH3B

Data Source:
BioGRID (two hybrid)

		DTX3	UBASH3B
Description		deltex E3 ubiquitin ligase 3	ubiquitin associated and SH3 domain containing B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Tyrosine Phosphatase Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphoprotein Binding
	Biological Process	Notch Signaling Pathway Protein Ubiquitination	Negative Regulation Of Protein Kinase Activity Negative Regulation Of Signal Transduction Peptidyl-tyrosine Dephosphorylation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Regulation Of Protein Binding Regulation Of Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Platelet Aggregation Negative Regulation Of Platelet Aggregation
Pathways
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Blood urea nitrogen levels ( 31152163) Cholesterol, total ( 24097068 25961943 20686565) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Eye length ( 30174134) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Pemphigus vulgaris ( 29857070) Serum immune biomarker levels ( 32066700) Stroke ( 26089329) Systolic blood pressure ( 30578418) Total cholesterol levels ( 28334899)
Interacting Genes		44 interacting genes: ARF5 BAG3 DTX1 DTX2 EPM2AIP1 FAM90A1 FYN GRB2 MAPK9 NCK2 NFKBID NOTCH2 OSTF1 PARP11 PTK6 RNF141 RNF38 TCEANC TRAF4 TRIP10 UBASH3A UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2DNL UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2W UEVLD USP1 USP2 USP21 XIAP YES1 ZDHHC17 ZMYND19	51 interacting genes: BBC3 CBL CBLB CCDC74B CUL3 DAZAP2 DISC1 DLGAP2 DMRT3 DOC2A DTX3 EFS FAM168A HOXB2 INCA1 JAK2 KAT5 KDM1A KHDRBS1 KPRP LMO2 LZTS2 MAP3K1 PIAS2 PKP4 PRKN PRR35 PSMB1 PTPN21 RCHY1 REL RNF216 RNF41 SHC1 SLC25A48 SPRY2 SYK TCF4 TEPSIN TNKS TP53BP2 UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H VPS37B WASL
Entrez ID		196403	84959
HPRD ID		16842	16463
Ensembl ID		ENSG00000178498	ENSG00000154127
Uniprot IDs		A0A024RB96 Q8N9I9	Q8TF42
PDB IDs			2CPW 2E5K 5VR6 5W5G
Enriched GO Terms of Interacting Partners?
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