SLC38A7 and APH1A

Data Source:
BioGRID (two hybrid)

		SLC38A7	APH1A
Description		solute carrier family 38 member 7	aph-1 homolog A, gamma-secretase subunit
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane Axon Neuronal Cell Body	Mitochondrion Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Integral Component Of Membrane Golgi Cisterna Membrane Gamma-secretase Complex Integral Component Of Presynaptic Membrane
	Molecular Function	L-histidine Transmembrane Transporter Activity L-glutamate Transmembrane Transporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-asparagine Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity L-methionine Transmembrane Transporter Activity L-serine Transmembrane Transporter Activity	Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity
	Biological Process	Amino Acid Transmembrane Transport Sodium Ion Transport Asparagine Transport Glutamine Transport Branched-chain Amino Acid Transport L-alanine Transport L-glutamate Transmembrane Transport Methionine Transport L-serine Transport L-aspartate Transmembrane Transport L-histidine Transmembrane Transport	Metanephros Development Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Endopeptidase Activity Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway
Pathways			Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs			E-2012
Diseases
GWAS		Plasma anastrozole concentration in anastrozole-treated estrogen receptor positive breast cancer ( 30648747) QT interval ( 19305408) Schizophrenia ( 25056061 29483656)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Morning vs. evening chronotype ( 26955885 26835600) Refractive error ( 32231278) Schizophrenia ( 25056061) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		52 interacting genes: ACBD5 AMIGO1 APH1A AQP2 AQP9 ARL13B BTNL9 CLCN7 CLDN7 CLEC10A CPLX4 CREB3L3 CYB561 CYB5R3 EDA ERGIC3 ERP29 EVI2B FAM209A FCER1G FKBP7 GJA8 GJB5 GPR152 GPR42 IL10RA KIR2DL3 LMNA LY6G6C LYVE1 MMGT1 MUC1 ODF4 OPRM1 PANX1 PDCD1LG2 RNF5 SCN3B SERP2 SHISAL1 SLC10A1 SLC16A2 SLC18A1 SLC23A2 SLC30A2 SPINT1 SSMEM1 SYPL2 TMEM237 TMEM52B TSPAN8 YIPF6	36 interacting genes: ANKRD46 APOD ASGR1 ATF4 BHLHE40 CREB3 DRD2 FIS1 FXYD6 GLP1R GPATCH8 GPR35 HES1 HIVEP1 IGFBP5 KLF11 LAT MFSD6 MPP1 MRAP2 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 SCAND1 SERP1 SLC38A7 SLC39A9 SMAGP THPO TLE1 TMED10 TMEM140 TMEM218 TRARG1
Entrez ID		55238	51107
HPRD ID		07701	06360
Ensembl ID		ENSG00000103042	ENSG00000117362
Uniprot IDs		H3BMC5 Q9NVC3	B4DUG7 Q96BI3
PDB IDs			5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC
Enriched GO Terms of Interacting Partners?
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