H3C1 and EZH2

Data Source:
BioGRID (enzymatic study, enzymatic study, affinity chromatography technology)

		H3C1	EZH2
Description		H3 clustered histone 1	enhancer of zeste 2 polycomb repressive complex 2 subunit
Image
GO Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein-containing Complex Extracellular Exosome	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Cytoplasm ESC/E(Z) Complex Pronucleus
	Molecular Function	DNA Binding Protein Binding Cadherin Binding Protein Heterodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Corepressor Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Chromatin DNA Binding Histone Methyltransferase Activity Ribonucleoprotein Complex Binding Histone Methyltransferase Activity (H3-K27 Specific) Primary MiRNA Binding Promoter-specific Chromatin Binding
	Biological Process	RDNA Heterochromatin Assembly Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly Blood Coagulation Telomere Organization Interleukin-7-mediated Signaling Pathway Cellular Protein Metabolic Process Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing By MiRNA Regulation Of Gene Silencing	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Chromatin Silencing At Telomere Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cardiac Muscle Hypertrophy In Response To Stress Histone Methylation Cerebellar Cortex Development Hippocampus Development B Cell Differentiation Response To Estradiol Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Trichostatin A Hepatocyte Homeostasis Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of GTPase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Cell Development Rhythmic Process Negative Regulation Of Striated Muscle Cell Differentiation Cellular Response To Hydrogen Peroxide G1 To G0 Transition Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Liver Regeneration Histone H3-K27 Trimethylation Positive Regulation Of Dendrite Development Positive Regulation Of Cell Cycle G1/S Phase Transition Response To Tetrachloromethane Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation Factors involved in megakaryocyte development and platelet production	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events
Drugs			Tazemetostat CPI-1205
Diseases
GWAS			Chronotype ( 30696823) Colorectal or endometrial cancer ( 26621817) Crohn's disease ( 28067908) Familial squamous cell lung carcinoma ( 29924316) Height ( 25282103 31562340) Inflammatory bowel disease ( 28067908) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		156 interacting genes: AIRE AKT2 ANP32A ANP32B ASH1L ASH2L ATXN1 AURKA AURKB AURKC BCAS3 CARM1 CBX1 CBX3 CENPM CENPT CENPW CHD3 CHD4 COPS2 CREBBP CTCFL CUL4A DCAF1 DDB1 DNAJC9 DNMT1 DNMT3A DNMT3B DPF2 DYRK1A EED EHMT1 EHMT2 EID1 EP300 ERCC6 ESCO1 EZH2 FANCD2 FBLIM1 GATAD2A GATAD2B GLYR1 GRIP1 H2AC20 H4C14 HASPIN HAT1 HDAC1 HDAC2 HDAC3 HDAC5 HDAC6 HDAC8 HDGFL3 HNF1B HNRNPA1 HNRNPAB HPF1 HSPA8 ING4 JMJD6 KAT14 KAT2B KAT5 KAT6A KAT7 KDM1A KDM2B KDM4A KDM4C KDM6A KDM6B KMT2A KMT2B KMT2C L3MBTL2 MAD2L1 MBD5 MLLT3 MPHOSPH8 MSL3 MYB NAP1L1 NASP NCOR1 NR1H4 NR3C1 NSD1 NSD2 NSD3 PAF1 PAK1 PALB2 PARP1 PARP10 PARP2 PAXIP1 PBRM1 PHF1 PHF19 PHF20 PHF8 PIKFYVE PPM1D PPP1CA PPP1CB PRDM2 PRKCA PRKCB PRMT1 PRMT5 PRMT7 PWWP3B RAD51B RAG1 RBBP4 RBBP7 RCC1 RPS6KA3 SETD1A SETD1B SETD2 SETD7 SETDB1 SIRT1 SIRT2 SIRT3 SIRT7 SMARCA2 SMARCA4 SMARCA5 SUV39H1 TAF15 TAF1A TAF1B THAP7 TLE3 TRIM33 TSSK6 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UHRF1 UHRF2 WDR5 WWC1 YEATS4 YWHAB YWHAG YWHAZ ZMYND8	77 interacting genes: AKT1 AR ATP1A1 ATP1B1 ATRX BCL11A BRCA1 C7orf25 CCDC85B CDK2 CDK6 CDKN2B-AS1 CEP63 CRY2 DELEC1 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EPC2 FBXW7 GADD45G GTF3C1 H1-1 H3-4 H3C1 HDAC1 HOTAIR JAK2 KAT2B KLHDC2 KRTAP10-9 LATS2 MAP3K20 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 MELK MUC1 MYCN NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRDM14 PRMT5 PSMB6 RASA1 RBL2 RELA RELB RIN3 RPN2 RPS6KA5 SIRT1 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 TRIM55 TRIM63 USP1 VAV1 WDR61 WSB2 ZMYND11
Entrez ID		8350	2146
HPRD ID		04155	03342
Ensembl ID		ENSG00000275714	ENSG00000106462
Uniprot IDs		P68431	A0A090N8E9 Q15910 S4S3R8
PDB IDs		1CS9 1CT6 1O9S 1Q3L 2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2CO0 2CV5 2FSA 2KWJ 2KWK 2L75 2LBM 2LGG 2M0O 2NDF 2NDG 2OQ6 2OT7 2OX0 2RI7 2RR4 2UXN 2V85 2V89 2VNF 2VPG 2X0L 3A1B 3AFA 3AVR 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3B95 3FDT 3KMT 3KQI 3LQI 3LQJ 3MP1 3O34 3O35 3O37 3QJ6 3RIG 3RIY 3SOU 3SOW 3U31 3U3D 3U4S 3U5N 3U5O 3U5P 3UEE 3UEF 3UIG 3UII 3UIK 3V43 3W96 3W97 3W98 3W99 3WA9 3WAA 3WKJ 3X1S 3X1T 3X1U 3X1V 3ZG6 3ZVY 4A0J 4A0N 4A7J 4BD3 4C1Q 4F4U 4F56 4FWF 4HON 4I51 4L7X 4LK9 4LKA 4LLB 4LXL 4N4H 4QBQ 4QBR 4QBS 4TN7 4U68 4UP0 4UY4 4X3K 4Y6L 4YHP 4YHZ 4YM5 4YM6 4Z0R 4Z2M 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5B24 5B2I 5B2J 5B31 5C11 5C13 5C3I 5CPI 5CPJ 5CPK 5D6Y 5DAH 5FB0 5FB1 5FFV 5GH9 5GSE 5GSU 5GT0 5GT3 5GTC 5H6Q 5H6R 5HJB 5HJC 5HJD 5HYN 5IQL 5J3V 5J9S 5JHN 5JIN 5JIY 5JJ0 5JRG 5KJH 5KJI 5KKL 5LUG 5M5G 5MR8 5NNC 5NND 5OY3 5SVX 5SVY 5SZB 5SZC 5T0K 5T0M 5T1G 5T1I 5T8R 5TBN 5TDR 5TDW 5U2J 5V21 5V22 5VA6 5VAB 5VGE 5VNB 5WFC 5WLE 5WVO 5WXG 5WXH 5WYI 5X60 5XF3 5XF4 5XF5 5XFQ 5XFR 5XNV 5XTZ 5Y0C 5Y0D 5Y20 5Y2F 5Z23 5Z30 6AXJ 6AZE 6BHD 6BHE 6BHG 6BHH 6BHI 6D07 6D08 6E83 6E86 6F6D 6HKT 6HTS 6IEU 6IIS 6IIT 6IPU 6IQ4 6JOU 6JR0 6JR1 6JXD 6K1I 6K1J 6K1K 6KE9 6KVD 6L49 6L4A 6L9H 6LA8 6LA9 6LE9 6M3V 6M44 6M4D 6M4G 6M4H 6MIL 6MIM 6MIN 6MIO 6MIQ 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6T90 6T93 6UPK 6UPL 6USJ 6V2H 6V3N 6V41 6V92 6VIL 6WAV 6WW4 6YIF 6YIH 6YOV 7C0M 7CCQ 7CCR	2C6V 4MI0 4MI5 5GSA 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5LS6 5U5T 5U62 5WG6 5WUK 6C23 6C24 6P5L 6U4Y
Enriched GO Terms of Interacting Partners?
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