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DVL3 and CLK1
Data Source:
BioGRID
(two hybrid)
DVL3
CLK1
Description
dishevelled segment polarity protein 3
CDC like kinase 1
Image
GO Annotations
Cellular Component
Chromatin
Cytosol
Nucleus
Cytoplasm
Molecular Function
Protease Binding
Signaling Receptor Binding
Frizzled Binding
Protein Binding
Beta-catenin Binding
Small GTPase Binding
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Intracellular Signal Transduction
Non-canonical Wnt Signaling Pathway
Non-canonical Wnt Signaling Pathway Via JNK Cascade
Response To Drug
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of GTPase Activity
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Neuron Projection Arborization
Regulation Of Cellular Protein Localization
Beta-catenin Destruction Complex Disassembly
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Regulation Of RNA Splicing
Protein Autophosphorylation
Pathways
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
PCP/CE pathway
PCP/CE pathway
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Drugs
Debromohymenialdisine
CHGN111
ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
Fostamatinib
Diseases
GWAS
Facial morphology traits (63 three-dimensional facial segments) (
29459680
)
Major depressive disorder (
22472876
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Breast cancer (
27117709
)
Breast cancer (estrogen-receptor negative) (
27117709
)
Triptolide cytotoxicity (
26121980
)
Interacting Genes
164 interacting genes:
ABT1
ADAP1
AKAP17A
ANKRD36B
AP3M1
AXIN1
BAHD1
BEND7
BHLHE40
C1orf35
C8orf33
CBX8
CCDC33
CCNK
CCNL1
CDYL2
CEP57L1
CEP70
CEP76
CLK1
CSNK1D
CSNK1E
CSNK2A1
CT45A10
CT45A3
CTNNB1
CYSRT1
DAB2
DDX54
DIDO1
DPPA2
DVL1
EIF1B
EIF3D
ENKD1
FAM13C
FAM90A1
FARS2
FGF16
FLACC1
GADD45GIP1
HOMER3
HOXA5
HOXC5
HOXC8
INO80B
KAT7
KAZN
KCTD10
KCTD7
KLF1
KLF15
KLF3
KLF4
KLHL12
LENG8
LNX1
LONRF1
LRRK2
LUZP4
LY6H
MAB21L3
MAGEB4
MAGOHB
MARK2
MATN2
NFYA
NKD1
NOL12
NXF1
PATZ1
PHF19
PIK3CB
PITX1
PLAGL2
PLN
PNKP
PPM1A
PPP1R16B
PPP2CA
PRKAA2
PRPF18
PRPF3
PRPF31
PRPF38A
PRR13
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSME3
PSMF1
RBM15B
RBM39
RNF151
RPL11
RPS10
RRP8
RWDD2B
SAP30L
SHFL
SNIP1
SNX22
SORBS3
STOM
SUV39H1
SYT6
SYTL4
TBPL1
TCEA2
TCEANC
TFG
THAP7
TLE5
TNFAIP8L1
TNP1
TPTEP2-CSNK1E
TRAF2
TRIM41
TRIM54
TSN
TSPYL1
TSPYL6
UTP3
VANGL1
VAX1
WDR25
WT1
XPA
YTHDC1
ZBTB24
ZBTB26
ZBTB47
ZBTB48
ZBTB8A
ZFP57
ZNF165
ZNF2
ZNF264
ZNF319
ZNF408
ZNF417
ZNF441
ZNF444
ZNF497
ZNF512B
ZNF552
ZNF581
ZNF648
ZNF696
ZNF697
ZNF699
ZNF71
ZNF764
ZNF774
ZNF775
ZNF792
ZNF821
ZNF837
ZRSR2
ZSCAN21
ZSCAN22
ZSCAN25
166 interacting genes:
ABCA13
ACOX2
ANKFY1
ARHGEF12
ARPC4
ASL
ASXL3
ATP10A
ATP4A
BCLAF1
C1orf94
CDCP1
CDH23
CDK12
CELSR3
CENPE
CEP95
CFAP20DC
CFAP251
CKAP5
CLASRP
CLK2
COCH
CRNKL1
CTNND2
CUL3
CWC27
CYP46A1
DBR1
DENND4A
DNAJC13
DNAJC24
DOCK9
DPYD
DSC2
DVL3
ECE1
ELP6
ENO1
ERFE
FAM189A1
FAT1
FBF1
FHIP2B
GEMIN5
GOLM1
GRM6
GSDMB
H2BC12
HADH
HIVEP1
HNMT
HNRNPA0
HNRNPA1
HNRNPA3
HSP90AB2P
HSPBP1
HTATSF1
ICE1
IMPDH2
IP6K1
ITGA5
KATNA1
KHDRBS1
KIF14
KIF23
KRT8
KRTAP10-6
KRTAP10-7
LINS1
LMNA
LNX1
LUC7L3
MAP3K21
MAP7
MBP
MFHAS1
MFSD10
MICU3
MKRN2
MTBP
MTCL1
MYOM1
NCL
NCOR1
NF1
NPM1
NUP153
PATZ1
PDE9A
PHF3
PHLDB2
PIAS4
PIP4K2B
PKD1L1
PLAAT5
PLXDC2
PPFIBP2
PPHLN1
PPIG
PPP1CB
PRDX5
PRKDC
PRMT5
PRPF38A
PRPF4
PRPF4B
PTPN1
PTPN22
RAD21L1
RAPH1
RASL12
RBBP6
RBM15
RBM39
RBMX
REV1
RLF
RPL5
RPS4Y1
RPUSD3
SAFB
SAMD9L
SCARA3
SERPINI2
SF3B1
SFMBT2
SH2B2
SHROOM1
SLC35D3
SLFN5
SPEN
SPTBN4
SRPK1
SRPK2
SRRM1
SRRM2
SRRM4
SRSF1
SRSF10
SRSF3
SRSF5
SRSF6
SRSF7
SSBP3
STIP1
STK31
SVOP
TEX11
THRAP3
THY1
TJP2
TLN2
TMPO
TMPRSS2
TNIP2
TP53RK
TRA2B
UBL5
UNC13B
VWA7
YTHDC1
YWHAG
ZC3H13
ZMYND10
ZNF148
Entrez ID
1857
1195
HPRD ID
03222
09058
Ensembl ID
ENSG00000161202
ENSG00000013441
Uniprot IDs
Q92997
Q9UG07
P49759
PDB IDs
6V7O
1Z57
2VAG
5J1V
5J1W
5X8I
6FT8
6FT9
6FYO
6G33
6I5H
6I5I
6I5K
6I5L
6KHD
6Q8K
6Q8P
6QTY
6R3D
6R6E
6R6X
6R8J
6RAA
6TW2
6YTA
6YTD
6YTE
6YTG
6YTI
6Z4Z
6Z50
6ZLN
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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