Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
DVL2 and BEND7
Data Source:
BioGRID
(two hybrid)
DVL2
BEND7
Description
dishevelled segment polarity protein 2
BEN domain containing 7
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Aggresome
Lateral Plasma Membrane
Nuclear Body
Cytoplasmic Vesicle
Apical Part Of Cell
Clathrin-coated Endocytic Vesicle
Extracellular Exosome
Molecular Function
Frizzled Binding
Protein Binding
Protein Kinase Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Identical Protein Binding
Protein Self-association
Protein Binding
Biological Process
Neural Tube Closure
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Regulation Of Transcription, DNA-templated
Segment Specification
Heart Development
Convergent Extension Involved In Neural Plate Elongation
Cellular Protein Localization
Hippo Signaling
Non-canonical Wnt Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of GTPase Activity
Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Neuron Projection Arborization
Beta-catenin Destruction Complex Disassembly
Pathways
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
Signaling by Hippo
PCP/CE pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD4
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS
Metabolite levels (
31628463
)
Metabolite levels (small molecules and protein measures) (
27005778
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Diastolic blood pressure (
30224653
)
Free thyroxine concentration (
30367059
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
PR interval (
32439900
)
Skin pigmentation (
28300201
)
Smoking status (ever vs never smokers) (
30643258
)
White blood cell count (
32888494
)
Interacting Genes
103 interacting genes:
ABL1
AKAP9
AP1M1
AP2M1
ARHGEF39
ARR3
ARRB1
ARRB2
ATN1
AXIN1
BAG3
BAHD1
BCL6
BEND7
BYSL
CARD9
CCDC33
CPSF7
CSNK1E
CTBP2
DAAM1
DCUN1D1
DDI1
DPPA2
DYNLT1
EIF1B
ELOA2
ENKD1
FAM161A
FAM90A1
FZD4
GABARAP
GABARAPL1
GMCL2
GOLGA2
GRAP2
GRB2
HIP1
IHO1
KLHL12
LMO3
LRRK2
MAGOHB
MAP1LC3A
MCRS1
NOL12
NUP62CL
OTULIN
PARD6A
PCBD1
PLA2G12A
POLI
PPM1A
PPP1R16B
PRKAA1
PRKCA
PRKCB
PRKCG
PRPF3
PRPF31
PSMF1
RAC1
RBFOX1
RBPMS
RHOA
RHOXF2
RNF185
RNPS1
RUNX2
RUSC1
SCNM1
SMURF1
SNF8
SNIP1
SORBS3
SSX2IP
TAB1
TDP2
THAP1
TIFA
TLE5
TP53
TPM3
TRAF2
U2AF2
UBAC1
UBE2D3
UIMC1
USP5
USP9X
VANGL1
VHL
WAS
WT1
YES1
ZBTB48
ZBTB8A
ZGPAT
ZNF165
ZNF250
ZNF263
ZNF410
ZNF581
73 interacting genes:
ANP32B
BANF2
BYSL
C14orf119
CDC37
CDCA7L
CEP44
CHD2
CIB3
CSNK2A1
DDX6
DVL2
DVL3
EAF1
EAF2
EIF1AD
EMD
FAM124A
FAM133A
GADD45G
GEMIN2
GTPBP3
GYS1
HMBOX1
HSF2BP
KANK2
L3MBTL2
LMO3
LNX1
LYAR
MAGOHB
MFAP1
MLX
MORF4L1
MORF4L2
MYO15B
NAP1L3
NEK6
NIF3L1
NKAPD1
NOL12
NUTF2
OSGIN1
PBLD
PIM1
PLEKHF2
POLR3GL
PPIG
PPP1R37
PRMT3
PRPF40A
PSMB1
PSMF1
RAB29
RBM10
RIPPLY1
RPL22
SCNM1
SDCBP
SDCBP2
SMARCA2
SPANXN2
THAP1
TLK1
TNPO2
TRIM26
U2AF2
UBL5
USP20
VCX2
WHRN
ZCCHC10
ZNF622
Entrez ID
1856
222389
HPRD ID
03690
12570
Ensembl ID
ENSG00000004975
ENSG00000165626
Uniprot IDs
O14641
Q8N7W2
PDB IDs
2REY
3CBX
3CBY
3CBZ
3CC0
4WIP
5LNP
5SUY
5SUZ
6IW3
6JCK
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?