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DVL2 and SCNM1
Data Source:
BioGRID
(two hybrid)
DVL2
SCNM1
Description
dishevelled segment polarity protein 2
sodium channel modifier 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Aggresome
Lateral Plasma Membrane
Nuclear Body
Cytoplasmic Vesicle
Apical Part Of Cell
Clathrin-coated Endocytic Vesicle
Nucleus
Nuclear Speck
Molecular Function
Frizzled Binding
Protein Binding
Protein Kinase Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Identical Protein Binding
Protein Self-association
Protein Binding
Enzyme Binding
Metal Ion Binding
Biological Process
Neural Tube Closure
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Regulation Of Transcription, DNA-templated
Segment Specification
Heart Development
Convergent Extension Involved In Neural Plate Elongation
Cellular Protein Localization
Hippo Signaling
Non-canonical Wnt Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of GTPase Activity
Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Neuron Projection Arborization
Beta-catenin Destruction Complex Disassembly
Alternative MRNA Splicing, Via Spliceosome
RNA Splicing
Pathways
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
Signaling by Hippo
PCP/CE pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD4
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS
Metabolite levels (
31628463
)
Metabolite levels (small molecules and protein measures) (
27005778
)
Interacting Genes
103 interacting genes:
ABL1
AKAP9
AP1M1
AP2M1
ARHGEF39
ARR3
ARRB1
ARRB2
ATN1
AXIN1
BAG3
BAHD1
BCL6
BEND7
BYSL
CARD9
CCDC33
CPSF7
CSNK1E
CTBP2
DAAM1
DCUN1D1
DDI1
DPPA2
DYNLT1
EIF1B
ELOA2
ENKD1
FAM161A
FAM90A1
FZD4
GABARAP
GABARAPL1
GMCL2
GOLGA2
GRAP2
GRB2
HIP1
IHO1
KLHL12
LMO3
LRRK2
MAGOHB
MAP1LC3A
MCRS1
NOL12
NUP62CL
OTULIN
PARD6A
PCBD1
PLA2G12A
POLI
PPM1A
PPP1R16B
PRKAA1
PRKCA
PRKCB
PRKCG
PRPF3
PRPF31
PSMF1
RAC1
RBFOX1
RBPMS
RHOA
RHOXF2
RNF185
RNPS1
RUNX2
RUSC1
SCNM1
SMURF1
SNF8
SNIP1
SORBS3
SSX2IP
TAB1
TDP2
THAP1
TIFA
TLE5
TP53
TPM3
TRAF2
U2AF2
UBAC1
UBE2D3
UIMC1
USP5
USP9X
VANGL1
VHL
WAS
WT1
YES1
ZBTB48
ZBTB8A
ZGPAT
ZNF165
ZNF250
ZNF263
ZNF410
ZNF581
177 interacting genes:
ADAMTSL4
AKAP9
AVPI1
AXIN2
BACH2
BEND7
BHLHB9
BLZF1
CALCOCO2
CARD10
CARD9
CBY2
CCDC136
CCDC28B
CCDC33
CCDC74B
CCDC85B
CDR2
CDR2L
CEP44
CEP70
CEP76
CHIC2
CIB3
COG6
CTDSP1
CYSRT1
CYTIP
DVL2
EZHIP
FAM161A
FAM228A
FANCL
FHL2
FHL5
FNDC11
FRS3
FSD2
GAS8
GIGYF1
GOLGA2
GOLGA6L9
HAP1
HMBOX1
HMG20A
HOMER3
HOMEZ
HOOK2
HSF2BP
IKZF1
IKZF3
INCA1
IRAK1BP1
JAKMIP1
KANK2
KATNBL1
KIFC3
KLF15
KRT27
KRT31
KRT33B
KRT34
KRT35
KRT38
KRT39
KRT75
KRTAP1-1
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP5-9
LCN2
LDOC1
LHX1
LHX3
LIMS1
LNX1
LNX2
LRP2BP
LZTS1
LZTS2
MCM6
MDFI
MEOX2
MID2
MIPOL1
MKRN3
MORN3
MRPL28
MSS51
MTUS2
MYLIP
MYO1F
NAB2
NAP1L2
NBPF19
NDUFB7
NFKBID
NOTCH2NLA
NUTM1
PBX4
PDE4DIP
PDLIM7
PFDN5
PIBF1
PICK1
PIH1D1
PLSCR1
PNMA1
PNMA2
PPP1R16A
PPP1R16B
PRDM14
PRNP
PRR5L
PSTPIP1
RBAK
RBM11
RBM48
RDM1
REL
RHOH
RINT1
RORB
RPGRIP1
RPH3AL
SMARCD1
SORBS3
SSX2IP
STX11
STX19
SYCE1
TAX1BP1
TFIP11
TLE5
TNNI1
TP53BP2
TRAF1
TRAF2
TRIB3
TRIM10
TRIM23
TRIM27
TRIM37
TRIM42
TRIM54
TTC23L
UBXN11
USH1G
USHBP1
VIM
VMAC
VPS52
VWC2
ZBTB1
ZBTB14
ZDHHC17
ZGPAT
ZIM2
ZMAT1
ZMYND12
ZNF135
ZNF19
ZNF20
ZNF202
ZNF438
ZNF511
ZNF526
ZNF547
ZNF552
ZNF641
ZNF688
ZNF76
ZNF774
ZNF829
Entrez ID
1856
79005
HPRD ID
03690
12162
Ensembl ID
ENSG00000004975
ENSG00000163156
Uniprot IDs
O14641
Q9BWG6
PDB IDs
2REY
3CBX
3CBY
3CBZ
3CC0
4WIP
5LNP
5SUY
5SUZ
6IW3
6JCK
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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