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DVL2 and SORBS3
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
DVL2
SORBS3
Description
dishevelled segment polarity protein 2
sorbin and SH3 domain containing 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Aggresome
Lateral Plasma Membrane
Nuclear Body
Cytoplasmic Vesicle
Apical Part Of Cell
Clathrin-coated Endocytic Vesicle
Nucleus
Cytosol
Cytoskeleton
Focal Adhesion
Molecular Function
Frizzled Binding
Protein Binding
Protein Kinase Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Identical Protein Binding
Protein Self-association
Structural Constituent Of Cytoskeleton
Protein Binding
Transcription Factor Binding
Vinculin Binding
Biological Process
Neural Tube Closure
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Regulation Of Transcription, DNA-templated
Segment Specification
Heart Development
Convergent Extension Involved In Neural Plate Elongation
Cellular Protein Localization
Hippo Signaling
Non-canonical Wnt Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of GTPase Activity
Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Neuron Projection Arborization
Beta-catenin Destruction Complex Disassembly
Negative Regulation Of Transcription By RNA Polymerase II
Muscle Contraction
Actin Filament Organization
Cell Adhesion
Cell-substrate Adhesion
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cytoskeleton Organization
Positive Regulation Of Stress Fiber Assembly
Pathways
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
Signaling by Hippo
PCP/CE pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD4
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Smooth Muscle Contraction
Drugs
Diseases
GWAS
Metabolite levels (
31628463
)
Metabolite levels (small molecules and protein measures) (
27005778
)
Diastolic blood pressure (
30224653
)
HIV-1 viral setpoint (
20205591
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Parkinson's disease (
28892059
)
Interacting Genes
103 interacting genes:
ABL1
AKAP9
AP1M1
AP2M1
ARHGEF39
ARR3
ARRB1
ARRB2
ATN1
AXIN1
BAG3
BAHD1
BCL6
BEND7
BYSL
CARD9
CCDC33
CPSF7
CSNK1E
CTBP2
DAAM1
DCUN1D1
DDI1
DPPA2
DYNLT1
EIF1B
ELOA2
ENKD1
FAM161A
FAM90A1
FZD4
GABARAP
GABARAPL1
GMCL2
GOLGA2
GRAP2
GRB2
HIP1
IHO1
KLHL12
LMO3
LRRK2
MAGOHB
MAP1LC3A
MCRS1
NOL12
NUP62CL
OTULIN
PARD6A
PCBD1
PLA2G12A
POLI
PPM1A
PPP1R16B
PRKAA1
PRKCA
PRKCB
PRKCG
PRPF3
PRPF31
PSMF1
RAC1
RBFOX1
RBPMS
RHOA
RHOXF2
RNF185
RNPS1
RUNX2
RUSC1
SCNM1
SMURF1
SNF8
SNIP1
SORBS3
SSX2IP
TAB1
TDP2
THAP1
TIFA
TLE5
TP53
TPM3
TRAF2
U2AF2
UBAC1
UBE2D3
UIMC1
USP5
USP9X
VANGL1
VHL
WAS
WT1
YES1
ZBTB48
ZBTB8A
ZGPAT
ZNF165
ZNF250
ZNF263
ZNF410
ZNF581
133 interacting genes:
ABI2
ABL1
ADAM15
ADAMTSL4
ADAT3
AKIRIN2
AKT2
ANKS1A
ARNT2
C1orf109
CATSPER1
CBFA2T2
CBLB
CCDC102B
CCDC120
CCDC187
CCDC57
CCDC6
CCHCR1
CCNH
CCNL1
CDC23
CDKN2C
CFAP206
CHERP
COG4
CPEB2
CPNE1
CPNE2
CPNE8
CPSF7
CRACR2A
DDX17
DDX6
DIP2A
DLG5
DMRTB1
DVL2
DVL3
EFHC1
EFS
EIF3H
ENKD1
FAM214B
FAM53C
FASLG
FBXL19
FLOT1
FNDC11
GAS8
GEM
GLRA1
GPANK1
GPKOW
GYS1
HGS
HNRNPF
HNRNPK
HNRNPUL1
IMP3
INPPL1
INSC
IQUB
KANK2
KIAA0408
KIAA1217
KIFC3
MAPK1
MAPK3
MKRN3
MYO15B
NAB2
NAF1
NCK1
NCKIPSD
NEK6
NFKBID
NHSL2
NOTCH3
NRBP1
OIP5
OSGIN1
PAK2
PAK5
PHETA1
PHF1
PIBF1
PLEKHN1
PLOD3
PNMA5
POLE2
POLR1C
PPFIA3
PPIL6
PPP1R18
QARS1
RAD51D
RBMX
RIN1
ROPN1
RUNX1T1
SAFB2
SAXO1
SCNM1
SETD5
SH2D4A
SOCS7
SPG21
SRCIN1
SYNPO2L
TBC1D22B
TCEANC
TEAD4
TEPSIN
TNS2
TRIM23
TRIM27
TRIM41
TSGA10
TSGA10IP
TXLNA
USP2
VARS2
VCL
VPS37B
VPS37C
WIPF2
ZBED1
ZBTB25
ZBTB7B
ZC2HC1C
ZC4H2
ZNF414
Entrez ID
1856
10174
HPRD ID
03690
11535
Ensembl ID
ENSG00000004975
ENSG00000120896
Uniprot IDs
O14641
O60504
PDB IDs
2REY
3CBX
3CBY
3CBZ
3CC0
4WIP
5LNP
5SUY
5SUZ
6IW3
6JCK
2CT3
2DLM
2NWM
2YUP
Enriched GO Terms of Interacting Partners
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