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DUSP6 and LMTK2
Data Source:
BioGRID
(two hybrid)
DUSP6
LMTK2
Description
dual specificity phosphatase 6
lemur tyrosine kinase 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Early Endosome
Golgi Apparatus
Cytosol
Integral Component Of Plasma Membrane
Integral Component Of Membrane
Growth Cone
Neuronal Cell Body
Receptor Complex
Perinuclear Region Of Cytoplasm
Recycling Endosome
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Tyrosine/threonine Phosphatase Activity
MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
Mitogen-activated Protein Kinase Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Phosphatase Inhibitor Activity
Protein Binding
ATP Binding
Myosin VI Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
MAPK Cascade
Activation Of MAPK Activity
Inactivation Of MAPK Activity
Protein Dephosphorylation
Response To Organic Cyclic Compound
Cell Differentiation
Peptidyl-tyrosine Dephosphorylation
Peptidyl-threonine Dephosphorylation
Response To Drug
Positive Regulation Of Apoptotic Process
Response To Nitrosative Stress
Regulation Of Heart Growth
Negative Regulation Of ERK1 And ERK2 Cascade
Response To Growth Factor
Receptor Recycling
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axonogenesis
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Endocytic Recycling
Negative Regulation Of Phosphoprotein Phosphatase Activity
Transferrin Transport
Positive Regulation Of Kinase Activity
Early Endosome To Late Endosome Transport
Protein Autophosphorylation
Pathways
RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway
Signaling by MAPK mutants
Drugs
Diseases
GWAS
Attention deficit hyperactivity disorder (
29325848
30478444
)
Night sleep phenotypes (
27126917
)
Gamma glutamyl transferase levels (
29403010
)
Hemoglobin levels (
32327693
)
Prostate cancer (
18264097
)
Interacting Genes
12 interacting genes:
AATK
ERBB4
LMTK2
LTK
MAPK1
MAPK3
MDFI
ROR2
SRPK1
TEX11
TXK
ZNF212
24 interacting genes:
CDC14A
CDC25C
CDK5
CDK5R1
DUSP14
DUSP19
DUSP29
DUSP6
ILKAP
MTMR6
PPM1A
PPM1F
PPM1K
PPP1CA
PPP1CB
PPP1CC
PPP1R2
PPP3CB
PTPDC1
PTPN12
PTPN6
PTPRR
STYX
TPTE2
Entrez ID
1848
22853
HPRD ID
04124
13994
Ensembl ID
ENSG00000139318
ENSG00000164715
Uniprot IDs
A0A024RBC1
Q16828
Q53GP9
Q8IWU2
PDB IDs
1HZM
1MKP
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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