DYNC1I2 and PPFIA1

Data Source:
BioGRID (two hybrid)

		DYNC1I2	PPFIA1
Description		dynein cytoplasmic 1 intermediate chain 2	PTPRF interacting protein alpha 1
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Vesicle	Cytoplasm Cytosol Focal Adhesion Presynaptic Active Zone
	Molecular Function	Microtubule Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Movement Regulation Of G2/M Transition Of Mitotic Cell Cycle Transport Along Microtubule Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Ciliary Basal Body-plasma Membrane Docking	Cell-matrix Adhesion Signal Transduction Neurotransmitter Secretion Glutamate Secretion Synapse Organization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs
Diseases
GWAS		Hippocampal volume ( 25625606) Metabolite levels ( 23823483) Refractive error ( 32231278) Weight ( 28552196)	Coronary artery disease ( 29212778) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		8 interacting genes: CCDC136 DCTN1 DYNLRB1 DYNLT1 DYNLT3 NECAB2 PNN PPFIA1	31 interacting genes: AGTPBP1 CAGE1 CAST CCNH CDK18 CEP70 DNAJC5 DTNB DYNC1I2 ELOA ERC1 ERC2 FAM161A GAS8 GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5A PPP2R5D PTPRC PTPRD PTPRF PTPRS TNNT1 TXLNA YWHAG
Entrez ID		1781	8500
HPRD ID		04512	11451
Ensembl ID		ENSG00000077380	ENSG00000131626
Uniprot IDs		A0A140VKE9 B4DPZ3 Q13409	B3KVS8 Q13136
PDB IDs		5JPW 6F1T 6F1U 6F1Z 6F38 6F3A	1N7F
Enriched GO Terms of Interacting Partners?
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