DYNC1I2 and DYNLRB1

Data Source:
BioGRID (two hybrid, affinity chromatography technology, proximity labelling technology, biochemical)

		DYNC1I2	DYNLRB1
Description		dynein cytoplasmic 1 intermediate chain 2	dynein light chain roadblock-type 1
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Vesicle	Cytoplasm Centrosome Cytoplasmic Dynein Complex Microtubule Cilium Membrane Ciliary Tip
	Molecular Function	Microtubule Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding	Microtubule Motor Activity Protein Binding Dynein Intermediate Chain Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Movement Regulation Of G2/M Transition Of Mitotic Cell Cycle Transport Along Microtubule Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Ciliary Basal Body-plasma Membrane Docking	Microtubule-based Movement Visual Behavior Intraciliary Transport Involved In Cilium Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Intraflagellar transport
Drugs
Diseases
GWAS		Hippocampal volume ( 25625606) Metabolite levels ( 23823483) Refractive error ( 32231278) Weight ( 28552196)	Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Pulse pressure ( 30224653)
Interacting Genes		8 interacting genes: CCDC136 DCTN1 DYNLRB1 DYNLT1 DYNLT3 NECAB2 PNN PPFIA1	9 interacting genes: CPEB1 CRCP DYNC1I1 DYNC1I2 HSPH1 MAGEA2 MAGEA2B MPHOSPH6 PALS2
Entrez ID		1781	83658
HPRD ID		04512	06203
Ensembl ID		ENSG00000077380	ENSG00000125971
Uniprot IDs		A0A140VKE9 B4DPZ3 Q13409	B4DFR2 Q9NP97
PDB IDs		5JPW 6F1T 6F1U 6F1Z 6F38 6F3A	1Z09 2B95 2E8J 2HZ5 6F1T 6F1Z 6F38 6F3A 6RLB 6SC2
Enriched GO Terms of Interacting Partners?
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