DCP2 and UPF2

Data Source:
HPRD (two hybrid)

		DCP2	UPF2
Description		decapping mRNA 2	UPF2 regulator of nonsense mediated mRNA decay
Image
GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol RISC Complex Cell Junction Cytoplasmic Ribonucleoprotein Granule	Nucleus Cytoplasm Cytosol Polysome Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function	5'-3' Exoribonuclease Activity Protein Binding Exoribonuclease Activity, Producing 5'-phosphomonoesters Manganese Ion Binding M7G(5')pppN Diphosphatase Activity Telomerase RNA Binding	RNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Telomerase RNA Localization To Cajal Body	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Worry/vulnerability (special factor of neuroticism) ( 30867560)	Diverticular disease ( 30177863)
Interacting Genes		12 interacting genes: AGO1 AGO2 DCP1A DCP1B MIR15B MTOR NAGK POLA2 PSMB1 TRIM21 UPF1 UPF2	76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		167227	26019
HPRD ID		13125	10405
Ensembl ID		ENSG00000172795	ENSG00000151461
Uniprot IDs		Q8IU60	Q9HAU5
PDB IDs		5MP0 5QOH 5QOI 5QOJ 5QOK 5QOL 5QOM 5QON 5QOO 5QOP 5QOQ 5QOR 5QOS 5QOT 5QOU 5QOV 5QOW 5QOX 5QOY 5QOZ 5QP0 5QP1 5QP2 5QP3 5QP4 5QP5 5QP6 5QP7 5QP8 5QP9 5QPA 5QPB 5QPC	1UW4 2WJV 4CEK 4CEM
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?