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KRT40 and BARD1
Data Source:
BioGRID
(two hybrid)
KRT40
BARD1
Description
keratin 40
BRCA1 associated RING domain 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Intermediate Filament
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
BRCA1-BARD1 Complex
Cytoplasmic Ribonucleoprotein Granule
BRCA1-A Complex
Molecular Function
Structural Molecule Activity
Protein Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Kinase Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
Biological Process
Keratinization
Cornification
DNA Double-strand Break Processing
Tissue Homeostasis
DNA Replication
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Protein Ubiquitination
Protein Deubiquitination
Negative Regulation Of MRNA 3'-end Processing
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Protein Export From Nucleus
Protein K6-linked Ubiquitination
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Keratinization
Formation of the cornified envelope
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
UCH proteinases
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Drugs
Diseases
GWAS
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
Feeling fed-up (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Neuroblastoma (
22941191
21124317
)
Neuroblastoma (high-risk) (
19412175
)
Neuroblastoma (MYCN amplification) (
28924153
)
Neurociticism (
29500382
)
Sporadic neuroblastoma (
28545128
)
Interacting Genes
381 interacting genes:
ACSF3
ADAMTS1
ADAMTSL3
AEN
AGXT
AKAP17A
ALDH3B1
ANKRD36BP1
AP1M1
AQP1
AQP5
ARID5A
ARMC7
ARSI
ASMTL
ATPAF2
AVPI1
AXIN1
BAHD1
BARD1
BCAS2
BEX2
BMS1P1
BRME1
BYSL
C10orf62
C11orf87
C19orf73
C1orf109
C1orf216
C22orf46
C2CD6
C2orf68
C4orf45
C5orf60
C6orf226
C8orf48
CA6
CARD9
CATIP
CBX8
CCDC112
CCDC116
CCDC120
CCDC146
CCDC185
CCDC198
CCDC26
CCDC93
CCER1
CCHCR1
CCNG1
CD33
CDC20B
CDK18
CDK5R1
CELA2B
CEP57
CEP57L1
CFAP206
CHCHD2
CHCHD3
CHIC2
CLEC18A
CNNM3
CNTF
COL8A1
COMT
COX5A
CREB5
CRY2
CTSZ
CWF19L2
CYCS
CYTH4
DAAM2
DCDC2B
DCX
DDX6
DHX57
DLGAP2
DMRT3
DOCK2
DOCK8
DTNB
EIF4E2
ELOA
ENKD1
EXOC3-AS1
FADS2
FAM107A
FAM124B
FAM214A
FAM27E3
FAM71C
FAM74A4
FAM90A1
FARS2
FASLG
FBF1
FBXL18
FBXO34
FBXW5
FEZF1
FKBP1B
FNDC11
FOXB1
FRG1
GAD1
GADD45GIP1
GATA2
GATAD2A
GEM
GFOD1
GGN
GLIDR
GNAI2
GNE
GNG5
GOLGA6L2
GPATCH2L
GTF3C5
GUCD1
HAPLN2
HAUS1
HBA2
HBZ
HCK
HDAC4
HGS
HNRNPLL
HOXA1
HOXB9
HOXC8
HSD3B7
HSF4
HSPA12B
HSPD1
ING5
INO80B
INPP5D
IQUB
ISCU
ITGB4
ITGB5
JOSD1
KANK2
KAT5
KCTD9
KDM1A
KIFC3
KLHL38
KPNA2
KRT2
KRT20
KRT4
KRT5
KRT6A
KRT6B
KRT6C
KRT71
KRT72
KRT75
KRT76
KRT8
KRT81
KRT82
KRT83
KRT85
KRT86
LAGE3
LCE3E
LENG1
LHX4
LIMS2
LIN37
LINC00636
LINC01588
LMF2
LMO1
LMO2
LMO4
LRCH4
MAB21L2
MAGOHB
MAPKBP1
MARK4
MED8
METTL17
MFAP1
MID2
MOB3C
MOBP
MOS
MRPL11
MRRF
MSRB3
MTA1
MXI1
MYPOP
NAB2
NAPRT
NDEL1
NEK6
NFKBID
NINJ1
NOL4L-DT
NPBWR2
NPPB
NR1D2
NXF1
ODAD4
OIP5
OPCML
OTUB2
PDLIM5
PGLS
PHF1
PHF21A
PHLDA1
PIGS
PIMREG
PIN1
PKD2
POLDIP3
POLL
POM121L8P
POP5
PPP1R18
PRAM1
PRKAA1
PRKAB2
PRPF18
PRPF31
PSMA1
PSMB1
PSMC5
PTGER3
PTPMT1
PXMP2
QPRT
RAB3IL1
RAB3IP
RAC1
RASSF5
RBM41
RCOR3
RECK
RGS8
RNF213
RNF6
RPL11
RSPH14
RTP5
RWDD2B
RXRB
SCAND1
SCOC
SEMA4C
SETD5
SH2D4A
SHC3
SHFL
SIRPA
SLC23A1
SLC25A10
SLIRP
SLU7
SMARCE1
SMCO4
SNAI1
SNHG11
SNRPB
SNW1
SPATA24
SPATC1L
SPEF1
SPG7
SRSF2
SSX2
SSX2IP
SUOX
SYT6
TACO1
TAPBPL
TBC1D16
TBC1D21
TBC1D22B
TCEA2
TCEANC
TCHP
TEAD4
THAP7
TIE1
TLE5
TMEM231
TMEM241
TMSB4X
TNIP3
TNNT1
TRAF4
TRIM42
TROAP
TRPV6
TSC22D4
TSGA10IP
TSHZ3
TTC23
TTC9C
TTLL10
TXLNA
TXN2
TXNDC5
TYK2
TYRO3
UACA
UBASH3A
UCMA
USHBP1
USP2
USP21
UTP14C
UTP23
UXT
VEZF1
WDR25
WT1
WT1-AS
ZBTB16
ZBTB24
ZBTB38
ZBTB42
ZC2HC1C
ZFHX3
ZFP1
ZFP2
ZFP69B
ZFYVE21
ZFYVE26
ZGPAT
ZMAT2
ZNF101
ZNF124
ZNF138
ZNF165
ZNF17
ZNF20
ZNF202
ZNF230
ZNF250
ZNF26
ZNF266
ZNF286A
ZNF317
ZNF319
ZNF329
ZNF337
ZNF408
ZNF410
ZNF417
ZNF438
ZNF439
ZNF446
ZNF488
ZNF490
ZNF564
ZNF569
ZNF575
ZNF580
ZNF581
ZNF587
ZNF625
ZNF655
ZNF688
ZNF697
ZNF702P
ZNF76
ZNF792
ZNF844
ZNRF2P1
ZSCAN21
125 interacting genes:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
AXIN2
BCCIP
BCL3
BRCA1
BRD7
CAP1
CBX1
CBX3
CBX5
CCDC136
CDK1
CDK2
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CSTF1
DCC
DDX39B
DNAI7
ELP1
ESR1
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AC20
H2AX
H2BC21
HAP1
HNRNPC
HNRNPLL
HSF2BP
HSPA14
IDI1
IKZF1
ING5
KAT5
KAT7
KBTBD7
KIFC3
KRT40
LDOC1
LGALS8
LRIF1
MACROH2A1
MAGED1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT-ND1
MT2A
MTUS2
NFKBIA
NPC2
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
PIN1
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RABEP1
RAD51
RBBP8
RBMY2BP
RPS20
SELENBP1
SETDB1
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TERF2
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WDR61
WRN
XRCC6
ZFP64
ZHX1
ZNF121
ZNF655
Entrez ID
125115
580
HPRD ID
08304
03354
Ensembl ID
ENSG00000204889
ENSG00000138376
Uniprot IDs
Q6A162
A0A087WZ19
A0AVN2
C9IYG1
F6MDI0
F6MDI1
F6MDI2
Q99728
PDB IDs
1JM7
2NTE
2R1Z
3C5R
3FA2
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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