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DDX1 and MIR140
Data Source:
BioGRID
(unspecified method)
DDX1
MIR140
Description
DEAD-box helicase 1
microRNA 140
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Cytoplasmic Stress Granule
Membrane
Cleavage Body
TRNA-splicing Ligase Complex
Ribonucleoprotein Complex
Extracellular Space
Molecular Function
DNA Binding
Chromatin Binding
Transcription Coregulator Activity
RNA Binding
RNA Helicase Activity
Helicase Activity
Nuclease Activity
Exonuclease Activity
Protein Binding
ATP Binding
Poly(A) Binding
DNA/RNA Helicase Activity
RNA Polymerase II Complex Binding
MRNA 3'-UTR Binding
MRNA Binding Involved In Posttranscriptional Gene Silencing
Biological Process
Spliceosomal Complex Assembly
Double-strand Break Repair
Regulation Of Transcription, DNA-templated
TRNA Splicing, Via Endonucleolytic Cleavage And Ligation
Regulation Of Translational Initiation
Multicellular Organism Development
Viral Process
DNA Duplex Unwinding
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Defense Response To Virus
Nucleic Acid Phosphodiester Bond Hydrolysis
Protein Localization To Cytoplasmic Stress Granule
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of BMP Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Gene Silencing By MiRNA
Defense Response To Bacterium
Cellular Response To Lipopolysaccharide
Cellular Response To Hypoxia
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Vascular Endothelial Growth Factor Production
Cellular Response To Amyloid-beta
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways
tRNA processing in the nucleus
Drugs
Diseases
GWAS
Asthma or chronic obstructive pulmonary disease (
24993907
)
Blood urea nitrogen levels (
31152163
)
Chronic kidney disease (
22479191
)
Chronic obstructive pulmonary disease (
30804561
)
Estimated glomerular filtration rate (
31152163
31015462
31451708
30604766
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Metabolite levels (
23823483
)
Pulmonary function (
21946350
)
Pulmonary function (smoking interaction) (
23284291
)
Severe COVID-19 infection with respiratory failure (analysis I) (
32558485
)
Urate levels (
31578528
)
Wilms tumor (
22544364
)
Body mass index (
26426971
)
Interacting Genes
83 interacting genes:
APP
ATM
CSTF2
ESR1
HNRNPK
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NDRG1
NME7
PTEN
RELA
SUMO2
YWHAQ
68 interacting genes:
ADARB1
AIMP1
APOBEC3B
C1QBP
CELF1
CELF2
CRTAP
CSTF1
DARS1
DDX1
DDX21
DDX3X
DDX49
EIF2AK2
EPRS1
FAM98A
FUS
G3BP2
HNRNPA0
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPF
HNRNPH1
HNRNPH2
HNRNPH3
HNRNPK
HNRNPL
HNRNPM
HNRNPR
IARS1
IGF2BP1
IGF2BP2
IGF2BP3
KARS1
KNOP1
LARP7
LIN28A
LRPPRC
MARS1
MATR3
NOL6
NONO
NUDT21
PDCD11
PIKFYVE
PIP5K1A
PTBP1
PTBP3
PUF60
PUM1
PURA
QARS1
RARS1
RBFOX2
RBM14
RTCB
SF3B1
SF3B3
SFPQ
SYNCRIP
TAF15
TRA2A
TRA2B
UPF1
UTP20
YBX1
YBX3
Entrez ID
1653
406932
HPRD ID
03158
Ensembl ID
ENSG00000079785
ENSG00000208017
Uniprot IDs
A3RJH1
Q92499
PDB IDs
4XW3
Enriched GO Terms of Interacting Partners
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