DDX1 and MIR214

Data Source:
BioGRID (unspecified method)

		DDX1	MIR214
Description		DEAD-box helicase 1	microRNA 214
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoplasmic Stress Granule Membrane Cleavage Body TRNA-splicing Ligase Complex Ribonucleoprotein Complex	Nucleus Perinuclear Region Of Cytoplasm Extracellular Vesicle
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity RNA Binding RNA Helicase Activity Helicase Activity Nuclease Activity Exonuclease Activity Protein Binding ATP Binding Poly(A) Binding DNA/RNA Helicase Activity	MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Spliceosomal Complex Assembly Double-strand Break Repair Regulation Of Transcription, DNA-templated TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Regulation Of Translational Initiation Multicellular Organism Development Viral Process DNA Duplex Unwinding Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Defense Response To Virus Nucleic Acid Phosphodiester Bond Hydrolysis Protein Localization To Cytoplasmic Stress Granule	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Gene Expression Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Gene Silencing By MiRNA Negative Regulation Of Necroptotic Process Cellular Response To Hypoxia Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Connective Tissue Replacement
Pathways		tRNA processing in the nucleus
Drugs
Diseases
GWAS		Asthma or chronic obstructive pulmonary disease ( 24993907) Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 22479191) Chronic obstructive pulmonary disease ( 30804561) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Metabolite levels ( 23823483) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Urate levels ( 31578528) Wilms tumor ( 22544364)	Height ( 31562340)
Interacting Genes		83 interacting genes: APP ATM CSTF2 ESR1 HNRNPK MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NDRG1 NME7 PTEN RELA SUMO2 YWHAQ	92 interacting genes: AIMP1 AIMP2 AQR ATXN2L C1QBP CDC5L CELF1 CPSF1 DARS1 DDX1 DDX21 DDX23 DDX3X DDX49 DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PTBP1 PTCD3 PUF60 PUM1 PUM2 QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM4 RBM4B RTCA RTCB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZC3H11A ZFR ZNF346
Entrez ID		1653	406996
HPRD ID		03158
Ensembl ID		ENSG00000079785	ENSG00000283844
Uniprot IDs		A3RJH1 Q92499
PDB IDs		4XW3
Enriched GO Terms of Interacting Partners?
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