KANK4 and CUL5

Data Source:
BioGRID (two hybrid)

		KANK4	CUL5
Description		KN motif and ankyrin repeat domains 4	cullin 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Cytoskeleton	Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity
	Biological Process	Negative Regulation Of Actin Filament Polymerization	G1/S Transition Of Mitotic Cell Cycle Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERBB2 Signaling Pathway Post-translational Protein Modification Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway
Pathways			Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Fuchs's corneal dystrophy ( 28358029) Regular attendance at a gym or sports club ( 29970889)	Refractive error ( 32231278)
Interacting Genes		6 interacting genes: CSK CUL5 HAT1 HOMER3 MYLIP TRAPPC6A	36 interacting genes: ANAPC11 ASB11 CCNB1IP1 CCNDBP1 COG6 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DEPTOR ELOA ERCC6 GHR GOLGA2 GPS1 KANK4 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBC UBE2F VHL
Entrez ID		163782	8065
HPRD ID		14109	03444
Ensembl ID		ENSG00000132854	ENSG00000166266
Uniprot IDs		B1ALP6 Q5T7N3	Q93034
PDB IDs			3DPL 3DQV 4JGH 4N9F 6V9I
Enriched GO Terms of Interacting Partners?
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