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DAXX and PNMA1
Data Source:
BioGRID
(two hybrid)
DAXX
PNMA1
Description
death domain associated protein
PNMA family member 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Nuclear Body
PML Body
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Molecular Function
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Protein Kinase Binding
Protein Kinase Activator Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Histone Binding
Protein N-terminus Binding
Androgen Receptor Binding
Sumo-dependent Protein Binding
Transcription Regulator Inhibitor Activity
Protein Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Nucleosome Assembly
Chromatin Remodeling
Regulation Of Transcription, DNA-templated
Activation Of JUN Kinase Activity
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Viral Process
Androgen Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Cellular Response To Heat
Cellular Response To Unfolded Protein
Regulation Of Apoptotic Process
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Cellular Response To Cadmium Ion
Cellular Response To Copper Ion
Cellular Response To Diamide
Positive Regulation Of Neuron Death
Cellular Response To Sodium Arsenite
Inflammatory Response To Antigenic Stimulus
Positive Regulation Of Apoptotic Process
Pathways
SUMOylation of transcription cofactors
Regulation of TP53 Degradation
HCMV Early Events
Inhibition of DNA recombination at telomere
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Autism spectrum disorder or schizophrenia (
28540026
)
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) (
30120083
)
Lung cancer (
28604730
)
Lung cancer in ever smokers (
28604730
)
Interacting Genes
113 interacting genes:
ACVR2A
AIRE
AMOTL2
AR
ATM
ATRX
BTBD6
CA12
CALCOCO2
CARD9
CARM1
CBS
CDCA7L
CENPC
CEP63
CEP70
CFLAR
CREBBP
CSNK2A1
DAPK3
DKC1
DMAP1
DNMT1
ESRRG
ETS1
FAM9B
FANCA
FAS
FASLG
FTH1
GAS8
GOLGA2
GOLGA6L9
GRIPAP1
H3-3A
H3-3B
H3-5
H3C3
H4-16
H4C6
HABP4
HBA1
HDAC1
HDAC2
HDAC3
HIPK1
HIPK2
HIPK3
HSF1
HSF4
HSPB1
KCTD4
MAP3K5
MCRS1
MDM2
MEN1
MIPOL1
MKRN1
MSANTD4
MX1
MYH11
NECAB2
NSD3
PARK7
PAX3
PAX5
PBXIP1
PIBF1
PLAGL1
PML
PNMA1
PRMT1
PTEN
RASSF1
RASSF3
RIPK3
RNF4
RPL13
SENP2
SERBP1
SLC2A4
SLC9A1
SNW1
SPN
SQSTM1
SSX2IP
STAT3
STK4
STUB1
SUMO1
SUMO2
SUMO3
TAX1BP1
TCF3
TCF4
TCF7L2
TFIP11
TGFB1
TGFBR2
TNFRSF1A
TP53
TP63
TP73
TRAF3
TRIM21
TRIM54
TSG101
UBC
UBE2I
USH1G
USP7
ZBTB2
ZBTB26
167 interacting genes:
ABHD17A
AGTR1
ANKRD36BP1
APTX
ARHGEF6
ARID5A
ASMTL
ATP5PO
ATP6V1G1
ATXN7
BEX2
BYSL
C1orf109
C21orf58
C8orf33
CARHSP1
CBX8
CCDC146
CCDC187
CCDC198
CCDC33
CCNG1
CCP110
CDK18
CFAP53
CHIC2
CHMP2B
CNNM3
COX5B
CTNNA3
DAXX
DCTN4
EAF2
EHHADH
ENKD1
FAM107A
FAM110A
FAM161A
FAM161B
FBF1
FBXL18
FEM1C
FMNL2
FOXD4L1
FOXD4L3
GADD45GIP1
GATA1
GEM
GPANK1
GPR25
GRAP2
GTPBP10
HAPLN2
HCK
HDAC4
HGS
HNRNPLL
HOXB9
IGFN1
INO80B
IVD
KANSL1
KAT2B
LAGE3
LENG1
LIN37
LMO3
LNX1
LSM2
MAB21L2
MACIR
MARK4
MCM7
MED8
METTL17
MRPL10
MRPL11
MRPL23
MSI1
MYO15B
MYOZ1
NIF3L1
NPBWR2
NSMF
NTAQ1
NUDT16L1
PARD3
PARD6B
PCGF6
PER1
PIN1
PIN4
PKN1
PKN3
PNMA5
PNMA6A
POLDIP3
POLL
POLM
PRKAB2
PRKCG
PRKCI
PRPF18
PRPF31
PSMA1
RAD51D
RAPGEF3
RBM41
RPP25
RPP25L
RSPH9
RSRC2
RTP5
RUSC1
SCAND1
SCNM1
SDCBP
SEMA4C
SH2D4A
SHC3
SHISA3
SLC25A48
SLIRP
SMIM3
SNRPB
SNRPB2
SPATC1L
SPG7
SSX2IP
STAMBPL1
SUV39H2
TASOR2
TCEA2
TCEANC
TCL1B
TEAD4
TMSB4X
TNNI1
TNNT1
TRIM42
TRIM73
TRPV6
TSHZ2
TSPYL4
TTC23
TTC9C
TXNDC9
UBQLN1
UBQLN4
URB1-AS1
USP2
VAV2
VBP1
VPS9D1
WDR25
WT1-AS
ZC2HC1C
ZCCHC12
ZFYVE26
ZG16B
ZNF148
ZNF35
ZNF410
ZNF438
ZNF564
ZNF581
ZNF688
Entrez ID
1616
9240
HPRD ID
04424
04926
Ensembl ID
ENSG00000204209
ENSG00000176903
Uniprot IDs
A0A024RCS3
B4E1C1
Q53F85
Q9UER7
Q8ND90
PDB IDs
2KQS
2KZS
2KZU
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
5GRQ
5KDM
5Y18
5Y6O
Enriched GO Terms of Interacting Partners
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