RIBC1 and EMILIN1

Data Source:
BioGRID (two hybrid, two hybrid)

		RIBC1	EMILIN1
Description		RIB43A domain with coiled-coils 1	elastin microfibril interfacer 1
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Collagen Trimer Extracellular Space Integrin Alpha4-beta1 Complex Collagen-containing Extracellular Matrix Extracellular Exosome EMILIN Complex
	Molecular Function	Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Integrin Binding Involved In Cell-matrix Adhesion
	Biological Process		Aortic Valve Morphogenesis Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Elastic Fiber Assembly Negative Regulation Of Cell Activation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Macrophage Migration
Pathways			Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		25 interacting genes: ATP6V0D2 BORCS6 CCNC EMILIN1 GOLGA2 GPSM1 HSF2BP KRT15 KRT31 KRT36 LDOC1 MISP MKRN3 MPPED2 OIP5 PFDN5 RINT1 TBC1D21 TEX11 TLE5 TOX2 TRIM23 TRIM27 USHBP1 VPS37C	29 interacting genes: ABI3 BEX3 BEX5 BFSP1 CDCA8 CENPQ COG7 DYNC1I1 EMILIN2 FBXO28 GNG13 IFT20 LAIR2 LRRIQ1 MIA2 MTMR9 NECAB2 NMI PLAC9 PRKAA2 RABGEF1 RIBC1 SNAPC5 TAB2 TAX1BP1 TSNAX YJU2 ZC2HC1C ZNF655
Entrez ID		158787	11117
HPRD ID		06553	00563
Ensembl ID		ENSG00000158423	ENSG00000138080
Uniprot IDs		A0A024R9X7 Q8N443	Q9Y6C2
PDB IDs			2KA3 2OII
Enriched GO Terms of Interacting Partners?
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