EMILIN1 and CENPQ

Data Source:
BioGRID (two hybrid)

		EMILIN1	CENPQ
Description		elastin microfibril interfacer 1	centromere protein Q
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Integrin Alpha4-beta1 Complex Collagen-containing Extracellular Matrix Extracellular Exosome EMILIN Complex	Kinetochore Nucleus Nucleoplasm Cytosol Actin Cytoskeleton
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Integrin Binding Involved In Cell-matrix Adhesion	Protein Binding
	Biological Process	Aortic Valve Morphogenesis Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Elastic Fiber Assembly Negative Regulation Of Cell Activation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Macrophage Migration	CENP-A Containing Nucleosome Assembly Metaphase Plate Congression Positive Regulation Of Protein Localization To Kinetochore
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		29 interacting genes: ABI3 BEX3 BEX5 BFSP1 CDCA8 CENPQ COG7 DYNC1I1 EMILIN2 FBXO28 GNG13 IFT20 LAIR2 LRRIQ1 MIA2 MTMR9 NECAB2 NMI PLAC9 PRKAA2 RABGEF1 RIBC1 SNAPC5 TAB2 TAX1BP1 TSNAX YJU2 ZC2HC1C ZNF655	14 interacting genes: AARD ABI2 ABI3 APP ATF2 BRME1 CCDC6 EMILIN1 HDAC7 HOMER1 KDM1A PLK1 SIKE1 SNX2
Entrez ID		11117	55166
HPRD ID		00563	10788
Ensembl ID		ENSG00000138080	ENSG00000031691
Uniprot IDs		Q9Y6C2	Q7L2Z9
PDB IDs		2KA3 2OII
Enriched GO Terms of Interacting Partners?
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