CYP11B2 and FDX1

Data Source:
HPRD (in vitro)

		CYP11B2	FDX1
Description		cytochrome P450 family 11 subfamily B member 2	ferredoxin 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane	Mitochondrion Mitochondrial Matrix
	Molecular Function	Steroid 11-beta-monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Heme Binding Corticosterone 18-monooxygenase Activity	Iron Ion Binding Electron Transfer Activity 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Regulation Of Blood Volume By Renal Aldosterone Renal Water Homeostasis C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Potassium Ion Homeostasis Sodium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus	C21-steroid Hormone Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Small Molecule Metabolic Process Cellular Response To CAMP Cellular Response To Forskolin
Pathways		Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)	Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Drugs		Spironolactone Osilodrostat	Mitotane
Diseases		Glucocorticoid-remediable aldosteronism (GRA) Aldosterone synthase deficiency; Corticosterone methyloxidase type I deficiency; Corticosterone methyloxidase type II deficiency
GWAS		Diastolic blood pressure ( 27841878 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) Medication use (diuretics) ( 31015401) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Pulse pressure ( 30487518) Systolic blood pressure ( 27841878 29403010 30487518 30578418)	Cognitive function ( 24684796) Coronary artery disease ( 32469254)
Interacting Genes		3 interacting genes: CYP11A1 CYP11B1 FDX1	5 interacting genes: CYCS CYP11A1 CYP11B2 FDXR PRKAB2
Entrez ID		1585	2230
HPRD ID		00492	00059
Ensembl ID		ENSG00000179142	ENSG00000137714
Uniprot IDs		P19099	P10109
PDB IDs		4DVQ 4FDH 4ZGX 6XZ8 6XZ9	3N9Y 3N9Z 3NA0 3NA1 3P1M
Enriched GO Terms of Interacting Partners?
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