FDX1 and FDXR

Data Source:
HPRD (in vitro)

		FDX1	FDXR
Description		ferredoxin 1	ferredoxin reductase
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Iron Ion Binding Electron Transfer Activity 2 Iron, 2 Sulfur Cluster Binding	Ferredoxin-NADP+ Reductase Activity NADPH-adrenodoxin Reductase Activity Oxidoreductase Activity
	Biological Process	C21-steroid Hormone Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Small Molecule Metabolic Process Cellular Response To CAMP Cellular Response To Forskolin	Generation Of Precursor Metabolites And Energy Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Ubiquinone Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process
Pathways		Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Drugs		Mitotane	Flavin adenine dinucleotide Nicotinamide adenine dinucleotide phosphate
Diseases
GWAS		Cognitive function ( 24684796) Coronary artery disease ( 32469254)
Interacting Genes		5 interacting genes: CYCS CYP11A1 CYP11B2 FDXR PRKAB2	4 interacting genes: FDX1 FHIT MTNR1A POU2F1
Entrez ID		2230	2232
HPRD ID		00059	00060
Ensembl ID		ENSG00000137714	ENSG00000161513
Uniprot IDs		P10109	A0A0A0MSZ4 A0A0A0MT64 A0A0A0MTN9 A0A0A0MTR6 A0A0C4DFN8 A0A0C4DGN7 P22570
PDB IDs		3N9Y 3N9Z 3NA0 3NA1 3P1M
Enriched GO Terms of Interacting Partners?
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