CYP11B2 and CYP11A1

Data Source:
HPRD (in vitro)

		CYP11B2	CYP11A1
Description		cytochrome P450 family 11 subfamily B member 2	cytochrome P450 family 11 subfamily A member 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Steroid 11-beta-monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Heme Binding Corticosterone 18-monooxygenase Activity	Iron Ion Binding Protein Binding Cholesterol Monooxygenase (side-chain-cleaving) Activity Heme Binding
	Biological Process	Regulation Of Blood Volume By Renal Aldosterone Renal Water Homeostasis C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Potassium Ion Homeostasis Sodium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus	C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Cortisol Metabolic Process Vitamin D Metabolic Process Cellular Response To Peptide Hormone Stimulus
Pathways		Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)	Pregnenolone biosynthesis Endogenous sterols Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Drugs		Spironolactone Osilodrostat	Aminoglutethimide
Diseases		Glucocorticoid-remediable aldosteronism (GRA) Aldosterone synthase deficiency; Corticosterone methyloxidase type I deficiency; Corticosterone methyloxidase type II deficiency	46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Congenital adrenal hyperplasia (CAH)
GWAS		Diastolic blood pressure ( 27841878 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) Medication use (diuretics) ( 31015401) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Pulse pressure ( 30487518) Systolic blood pressure ( 27841878 29403010 30487518 30578418)	Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132)
Interacting Genes		3 interacting genes: CYP11A1 CYP11B1 FDX1	5 interacting genes: CYP11B2 FDX1 SMAD2 SMAD3 SMAD9
Entrez ID		1585	1583
HPRD ID		00492	00326
Ensembl ID		ENSG00000179142	ENSG00000140459
Uniprot IDs		P19099	A0A0S2Z3R3 P05108
PDB IDs		4DVQ 4FDH 4ZGX 6XZ8 6XZ9	3N9Y 3N9Z 3NA0 3NA1
Enriched GO Terms of Interacting Partners?
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