CTRB1 and SERPINF2

Data Source:
HPRD (in vitro)

		CTRB1	SERPINF2
Description		chymotrypsinogen B1	serpin family F member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Proteolysis Digestion Cobalamin Metabolic Process Extracellular Matrix Disassembly	Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Platelet Degranulation Acute-phase Response Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Activation of Matrix Metalloproteinases Cobalamin (Cbl, vitamin B12) transport and metabolism	Platelet degranulation Dissolution of Fibrin Clot
Drugs		Trans-O-Hydroxy-Alpha-Methyl Cinnamate 2,4-Dihydroxy-Trans Cinnamic Acid Phenylethane Boronic Acid Phosphorylisopropane Aprotinin 1,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE) N-(1-BENZYL-3,3,3-TRIFLUORO-2,2-DIHYDROXY-PROPYL)-ACETAMIDE alpha-Methyl-2-hydroxy-4-diethylaminocinnamic acid 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (1-FORMYL-2-PHENYL-ETHYL)-AMIDE (2S) N-acetyl-L-alanyl-Î±L-phenylalanyl-chloroethylketone 1,1,1-TRIFLUORO-3-((N-ACETYL)-L-LEUCYLAMIDO)-4-PHENYL-BUTAN-2-ONE(N-ACETYL-L-LEUCYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE) Phenylalanylmethylchloride L-1-naphthyl-2-acetamido-ethane boronic acid D-1-naphthyl-2-acetamido-ethane boronic acid D-1-(4-chlorophenyl)-2-(acetamido)ethane boronic acid L-1-(4-chlorophenyl)-2-(acetamido)ethane boronic acid	Ocriplasmin Copper
Diseases			Alpha-2-plasmin inhibitor (a2-PI) deficiency
GWAS		Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 29875488) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Pancreatic cancer ( 25086665) Type 2 diabetes ( 30054458)	Blood protein levels ( 29875488) Calcium levels ( 24068962 20705733) Serum albumin level ( 23022100 29403010) Urate levels ( 31578528)
Interacting Genes		4 interacting genes: LYPD3 SERPINA1 SERPINA3 SERPINF2	17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2
Entrez ID		1504	5345
HPRD ID		00345	02029
Ensembl ID		ENSG00000168925	ENSG00000167711
Uniprot IDs		P17538	P08697
PDB IDs
Enriched GO Terms of Interacting Partners?
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