SERPINF2 and KLK13

Data Source:
HPRD (in vitro)

		SERPINF2	KLK13
Description		serpin family F member 2	kallikrein related peptidase 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Cytoplasm Secretory Granule
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity	Serine-type Endopeptidase Activity Protein Binding Hydrolase Activity
	Biological Process	Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Platelet Degranulation Acute-phase Response Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Proteolysis Protein Processing Cornification
Pathways		Platelet degranulation Dissolution of Fibrin Clot	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Formation of the cornified envelope
Drugs		Ocriplasmin Copper
Diseases		Alpha-2-plasmin inhibitor (a2-PI) deficiency
GWAS		Blood protein levels ( 29875488) Calcium levels ( 24068962 20705733) Serum albumin level ( 23022100 29403010) Urate levels ( 31578528)	Blood protein levels ( 30072576)
Interacting Genes		17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2	3 interacting genes: A2M SERPINA3 SERPINF2
Entrez ID		5345	26085
HPRD ID		02029	05693
Ensembl ID		ENSG00000167711	ENSG00000167759
Uniprot IDs		P08697	A0A1R3UCE9 Q5BQ99 Q86VI7 Q9UKR3
PDB IDs
Enriched GO Terms of Interacting Partners?
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